广东医学2018，Vol.39Issue(1)：103-106,4.
促性腺激素释放激素激动剂长方案对不同类型PCOS患者IVF-ET后妊娠结局的影响
Effect of IVF-ET outcome on different types of PCOS patients treated with GnRH agonist long protocol
摘要
Abstract
Objective To compare in vitro fertilization and embryo transfer(IVF-ET)outcome between hy-perandrogenism polycystic ovarian syndrome(PCOS)patients and no hyperandrogenism PCOS patients treated with go-nadotriopin-releasing hormone(GnRH)agonist long protocol.Methods Patients with PCOS,who underwent IVF -ET with GnRHa regulation in reproductive medical center of the third affiliated hospital of Guangzhou Medical University from 2011 to 2015,were enrolled and divided into two groups according to theirs serum testosterone,the hyperandrogenism P-COS group(Group A,n=538 patients)and non-hyperandrogenism PCOS group(Group B,n=181).We recorded and compared their general condition(women and men age,infertility duration,the basic hormone level,body mass index), get-egg and embryo transfer situation(the profile hormone level and endometrial thickness on the day of HCG administra-tion,the number of oocytes, the day and the number of transferred embryos)and pregnancy outcome(pregnancy rate, live birth rate,abortion rate and ectopic pregnancy rate).Results There was no significant difference in women and men age,infertility duration,basic FSH,live birth rate,LH,P,E2on the day of HCG administration,or abortion rates of ear-lier and later phase between the 2 groups(P>0.05).The basic E2and LH,BMI, endometrial thickness on the day of HCG administration,pregnancy rate,and abortion rate in Group A was significantly higher than those in Group B,but the ectopic pregnancy rate and multiple pregnancy rate in Group A was significantly lower than those in Group B(P<0.05). Conclusion GnRHa long protocol is the optimal choice for the hyperandrogenism PCOS patients, it can efficiently im-prove the metabolic disorders and increase the pregnancy rate of the patients, but miscarriage rate is also increased, so more concern is needed after IVF -ET.关键词
多囊卵巢综合征/高雄激素血症/GnRH激动剂/体外受精-胚胎移植/妊娠结局Key words
PCOS/hyperandrogenism/GnRHa/IVF-ET/pregnancy outcome引用本文复制引用
吴曼,肖国宏,杨洁,张莹莹,宋霁,陈金曼..促性腺激素释放激素激动剂长方案对不同类型PCOS患者IVF-ET后妊娠结局的影响[J].广东医学,2018,39(1):103-106,4.基金项目
广东省生殖医学重点实验室建设项目(编号:粤科财字〔2012〕125号) （编号:粤科财字〔2012〕125号）
