光通信技术2018，Vol.42Issue(1)：34-37,4.DOI:10.13921/j.cnki.issn1002-5561.2018.01.010
基于RCWA的蛋白质光学生物传感器的研究
Research on protein optical biosensor based on RCWA
摘要
Abstract
This paper designs protein optical biosensor, theoretically analyzes the sensor by rigorous coupled wave(RCWA) method, analyzes the relationship between the reflectivity of sensitive media membrane system from the sensor and laser incidence angle and the refractive index, thickness of the protein by computer simu-lation. From the simulation results can be obtained: the reflectivity of sensitive media membrane system from the sensor and the laser incidence angle and refractive index, thickness, incidence angle of the protein has a good linear response characteristic, and the sensitivity increases with the increase of thickness. So that the re-fractive index of the protein can be obtained by detecting the reflectance of sensitive media membrane system from the sensor and the laser incident angle, and can control the thickness of antibodies and antigens to in-crease or decrease the sensitivity. The optical biosensors designed can be used to detect the type and content of proteins, it has the advantages of high sensitivity, real-time and no mark.关键词
光学生物传感器/蛋白质检测/严格耦合波分析法(RCWA)/反射率/折射率Key words
optical biosensor/protein detection/RCWA/reflectivity/refractive index分类
数理科学引用本文复制引用
黄子吉,任哲毅,肖杰,白忠臣,陆安江..基于RCWA的蛋白质光学生物传感器的研究[J].光通信技术,2018,42(1):34-37,4.基金项目
国家科技支撑计划(2015BAK28B02)资助 （2015BAK28B02）
国家国际合作专项(2014DFA00670)资助 （2014DFA00670）
贵州省科技重大专项(黔科合重字[2016]3022号)资助. （黔科合重字[2016]3022号）
