扬州大学学报（农业与生命科学版）2017，Vol.38Issue(4)：35-38,55,5.DOI:10.16872/j.cnki.1671-4652.2017.04.007
板蓝根水提物对2型糖尿病大鼠血管损伤的保护作用
Protecting function of water extract of Isatidis radix on vascular injury in rats with type 2 diabetes
摘要
Abstract
To investigate the effect of water extract of Isatidis radix (WEIR) on type 2 diabetic rats.The model mentioned above was gavaged with WEIR or captopril to investigate the effect of WEIR on rats.After four weeks of administration,the concentration of nitric oxide (NO),nitric oxide synthase (NOS),monocyte chemotaxis protein-1 (MCP-1),endothelin-1 (ET-1) and intercellular cell adhesion molecule-1 (ICAM-1) were measured.The pathological change of aortas was observated by hematoxylin eosin stain.The results showed that compared with the model group,the nitric oxide synthase activity,concentration of nitric oxide in captopril group and WEIR groups were increased,and the concentration of ET-1,MCP-1 and ICAM 1 were decreased.The aortic endothelial cells and smooth muscle cells of the model group were proliferated,and the smooth muscle cells of the model group were arranged disordered and distorted.The aortas of the WEIR groups and captopril group were significantly improved.It was concluded that WEIR could protect the aorta of diabetic rats,which may be related to the increase of serum NO,NOS and decrease of serum ET-1,MCP-1 and ICAM-1 level.关键词
板蓝根水提物/糖尿病大鼠/血管内皮损伤Key words
water extract of Isatidis radix/diabetic rats/vascular injury分类
医药卫生引用本文复制引用
李吉萍,胡天娇,张文友,刘墨祥..板蓝根水提物对2型糖尿病大鼠血管损伤的保护作用[J].扬州大学学报（农业与生命科学版）,2017,38(4):35-38,55,5.基金项目
江苏省苏北星火带科技攻关项目(BE2004339) （BE2004339）
