检验医学与临床2018，Vol.15Issue(4)：463-466,4.DOI:10.3969/j.issn.1672-9455.2018.04.010
锌转运蛋白8在1型糖尿病诊断中的敏感性和特异性研究
Sensitivity and specificity of zinc transporter 8 in the diagnosis of type 1 diabetes mellitus
摘要
Abstract
Objective To investigate the sensitivity and specificity of zinc transporter 8(ZnT8A)in the di-agnosis of type 1 diabetes mellitus(T1DM).Methods From February 2014 to December 2015,48 T1DM pa-tients in our hospital were selected as the T 1DM group,and the the 96 patients with T2DM were selected as T2DM group,96 cases of healthy people were selected as the healthy control group,all the cases were detected with ZnT8A and conventional index and were given correlation analysis.Results The positive threshold in healthy control group was 0.011,the positive rate of ZnTSA was 2.1%,the positive rate of ZnTSA in the T1DM group was 37.5%,the positive rate of ZnTSA in the T2DM group was 4.2%,the positive rate of ZnT-SA in the T1DM were significantly higher than those of healthy control group and T 2DM group(P<0.05), and there were no significant difference compared between the healthy control group and T 2DM group(P>0.05).The FBG and 2 h PG in the T2DM group and T1DM group were significantly higher than that of the healthy control group(P<0.05),and there were significant difference compared between the T 2DM group and T1DM group(P>0.05),the TC,TG,LDL-C,HDL-C compared among the three groups were not statistically significant(P>0.05).Use the the positive rate of ZnTSA 10.0%,the FBG ≥7.0 mmol/L,2 h PG ≥12.0 mmol/L as the diagnostic threshold,the sensitivity and specificity in the diagnosis of T 1DM were 97.63% and 98.22%,45.69% and 94.34%,48.20% and 96.20%,Spearman correlation analysis showed that the positive rate of ZnTSA were positive correlation to the FBG and 2 h PG(P<0.05).Conclusion The positive rate of ZnTSA in the T1DM group show high expression,and has significant positive correlation to the FBG and 2 h PG,it can improve the specificity of diagnosis of the T 1DM and has good application values.关键词
锌转运蛋白8/1型糖尿病/敏感性/特异性/相关性Key words
zinc transporter 8/type 1 diabetes mellitus/sensitivity/specificity/correlation分类
医药卫生引用本文复制引用
赵鸿斌,祁洁,孙晓慧,李彦青..锌转运蛋白8在1型糖尿病诊断中的敏感性和特异性研究[J].检验医学与临床,2018,15(4):463-466,4.基金项目
河北省石家庄市卫生和计划生育委员会基金项目(151461163). （151461163）
