检验医学与临床2018，Vol.15Issue(4)：475-477,481,4.DOI:10.3969/j.issn.1672-9455.2018.04.014
硫唑嘌呤对炎性肠病患者的治疗效果及药物不良反应研究
Study on the treatment of azathioprine in patients with inflammatory bowel disease
耿颖1
作者信息
- 1. 湖南省脑科医院消化内科,长沙410007
- 折叠
摘要
Abstract
Objective The aim of this research is to analyse the effectiveness and adverse reaction of aza-thioprine(AZA).Methods A total of 40 inflammatory bowel disease(IBD)patients treated with AZA were collected.The dose,course of treatment and the condition of adverse reaction were studied.The impact factor of the adverse reaction were analyzed by multivariate ogistic regression analysis.Results There were 18 IBD patients w ho had adverse reaction,accounting for 45.0%,including 5 cases of hepatotoxicity (12.5% ),11 ca-ses of bone marrow suppression(27.5% ),1 case of infection(2.5% ) and 1 case gastrointestinal symptom (2.5% ).The average incidence of adverse reactions was(3.09 ± 2.65)months,which occurred in 1 week in 3 cases.The appearance of hepatotoxicity was related to the dose and the increasing of the dose of AZA.But there was no relation of adverse reaction to the time of drug taken.Conclusion The rate of adverse reaction of azathioprine is 45.0%.The time of adverse reactions is(3.09 ± 2.65)months.The appearance of hepatotoxici-ty is related to the dose and the increasing of the dose of azathioprine.关键词
炎性肠病/硫唑嘌呤/硫嘌呤甲基转移酶/不良反应Key words
inflammatory bowel disease/azathioprine/thiopurine-S-methyltransferase/adverse drug reaction分类
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耿颖..硫唑嘌呤对炎性肠病患者的治疗效果及药物不良反应研究[J].检验医学与临床,2018,15(4):475-477,481,4.
