Abstract
Objective To explore the effect of glutamine on intestinal permeability and plasma level of two amine oxidase in patients with severe traumatic brain injury.Methods A total of 78 patients with severe brain injury in our hospital intensive care unit from September 2014 to March 2016 were selected into clinical re-search,they were divided into two groups according to the single number of reception time number,all take comprehensive treatment,39 cases with a single number as the control group,they were given general nutrition support,39 cases of double number as the observation group were given glutamine enhanced,analyze the difference of curative effect.Results The nutritional and metabolic indexes after treatment of the observation group were ALB(37.78 ± 4.20)g/L,TRF(2.38 ± 0.36)g/L,PA(0.48 ± 0.04)g/L and were significantly in-creased(t=7.70,7.48,6.80,P<0.05);there were significant differences compared with the control group(t=7.03,6.87,6.30,P<0.05).After treatment the levels of IgA(2.79 ± 0.36)g/L,IgG(13.76 ± 1.64)g/L,IgM (2.28 ± 0.42)g/L of the observation group significantly increased than those before treatment(t=7.43,7.30, 7.04,P<0.05);And there was significant difference compared with those in the control group(t=6.60,6.81, 6.30,P<0.05).Compared with the control group,the rate of milk fructose excretion 3 d[(0.25 ± 0.05)% ] and 7 d[(0.18 ± 0.06)]% in the observation group significantly reduced(t=6.56,6.81,P<0.05),DAO of 3 d and 7 d[(2.92 ± 0.25),(1.57 ± 0.18)U/mL]significantly reduced(t=7.20,6.92,P<0.05),D-lactic acid at 1,3,7 d were[(0.19 ± 0.04),(0.15 ± 0.05),(0.09 ± 0.06)μg/L],LPS at 3 d[(0.27 ± 0.06)U/mL,7 d(0.16 ± 0.03)U/mL]significantly reduced(t=7.52,8.02,8.29,P<0.05),the above indexes significantly re-duced than those in the control group(t=6.88,7.20,P<0.05).Conclusion Using of glutamine in patients with severe brain injury can correct nutritional and metabolic disorders,improve the nutritional status of pa-tients,protect the intestinal mucosal barrier function,improve the body immunity,can provide the reference for clinical application and use for reference.关键词
丙氨酰谷氨酰胺/重型颅脑损伤/肠黏膜通透性Key words
glutamine/severe brain injury/intestinal permeability分类
临床医学
