环境与职业医学2018，Vol.35Issue(1)：83-88,6.DOI:10.13213/j.cnki.jeom.2018.17592
非编码RNA在微囊藻毒素-LR致毒中作用的研究进展
Review on role of non-coding RNA in microcystin-LR toxicity
摘要
Abstract
Microcystin-LR (MC-LR) is one of the most toxic microcystins produced by cyanobacteria,posing a serious threat to ecological environment and public health.Previous studies have shown that MC-LR may cause toxicity by inhibiting protein phosphatase activity and inducing oxidative stress and DNA damage.However,the associated mechanism of its toxicity remains unclear.Non-coding RNA (ncRNA) is a class of RNA molecules that do not encode proteins,playing an important role in mediating inflammation,tumor genesis and development,and the toxicity of exogenous chemicals.Recent studies have shown that ncRNA is involved in the regulation of MC-LR toxicity.This paper reviewed the role of ncRNA in mediating MC-LR toxicity,aiming to provide an insight for further study on the mechanism of MC-LR toxicity.关键词
微囊藻毒素-LR/非编码RNA/毒性/毒性机制Key words
microcystin-LR/non-coding RNA/toxicity/toxic mechanism分类
医药卫生引用本文复制引用
杨书,杨飞,冯湘玲,陈继华,文聪,陈律..非编码RNA在微囊藻毒素-LR致毒中作用的研究进展[J].环境与职业医学,2018,35(1):83-88,6.基金项目
国家自然科学基金面上项目(编号:81773393,81472972) （编号:81773393,81472972）
国家自然科学青年基金项目(编号:81502787) （编号:81502787）
湖南省自然科学青年基金项目(编号:2016JJ3166) （编号:2016JJ3166）
中国博士后科学基金特别资助(编号:2016T90766) （编号:2016T90766）
中国博士后科学基金项目(编号:2015M572273) （编号:2015M572273）
