南京医科大学学报（自然科学版）2017，Vol.37Issue(12)：1583-1586,4.DOI:10.7655/NYDXBNS20171209
克罗米芬组合低剂量促性腺激素方案和常规拮抗剂方案在体外授精胚胎移植治疗中的临床治疗结局比较
Comparison of clinical outcomes between clomiphene citrate combined with low-dose gonadotropin and conventional antagonist protocol in the treatment of in vitro fertilization and embryo transfer
摘要
Abstract
Objective:To compare the clinical outcomes of patients with normal ovarian function in vitro fertilization and embryo transfer therapy,using clomiphene citrate combined with low dose gonadotropin regimen and conventional antagonist regimen.Methods:A prospective randomized controlled trial was conducted.One hundrend and tweenty couples were selected from September 2014 to December 2015 at the First Affiliated Hospital of NJMU,the normal ovarian function of the woman and the in vitro fertilization embryo transfer therapy.The women were divided into experimental group (clomiphene citrate combination low dose gonadotropin regimen) and control group (conventional antagonist regimen) according to the randomized digital envelope method.Both of the two groups All embryo were frozen and frozen-thawed embryos were transfered,followed-up to live or running out of all embryos of this cycle in two groups,compare the clinical and laboratory results and clinical outcomes of the two groups were compared.Results:The dosage of gonadotropin in the experimental group was lower than that in the control group.The stimulate time of gonadotropin was shorter than that of the control group.There was no significant difference in clinical pregnancy rate and cumulative live birth rate between two groups.Conclusion:The combination of clomiphene citrate and low dose gonadotropin program can achieve the clinical outcome as good as the conventional antagonist regimen in the case of reduced dosage of gonadotropin and shortened stimulation days.It is a new economical,effective and mild ovulation induction program.关键词
克罗米芬/促性腺激素/体外授精/胚胎移植/临床妊娠率/活产率Key words
clomiphene citrate/gonadotropin/in vitro fertilization/embryo transfer/clinical pregnancy rate/live birth rate分类
医药卫生引用本文复制引用
吴畏,冒韵东,王媁,蔡令波,马翔,刁飞扬,孟艳,刘嘉茵..克罗米芬组合低剂量促性腺激素方案和常规拮抗剂方案在体外授精胚胎移植治疗中的临床治疗结局比较[J].南京医科大学学报（自然科学版）,2017,37(12):1583-1586,4.基金项目
国家科技重大专项子课题(2017YFC1001300) （2017YFC1001300）
