内科理论与实践2017，Vol.12Issue(6)：375-379,5.DOI:10.16138/j.1673-6087.2017.06.003
特利加压素治疗发生低钠血症的危险因素分析
Risk factors of hyponatremia caused by terlipressin treatment
周郁芬 1忻笑容 1谢玲 1俞骁珺 1谷雷雷 1陈平 1袁晓琴 1许兰涛 1吴云林1
作者信息
- 1. 上海交通大学医学院附属瑞金医院北院消化内科,上海201801
- 折叠
摘要
Abstract
Objective To analysis the risk factors of hyponatremia caused by terlipressin.Methods Thirty-two patients with acute variceal bleeding caused by liver cirrhosis and treated with terlipressin from January 2013 to December 2016 were analyzed retrospectively.The risk factors for the decrease in serum sodium level following terlipressin administration were analyzed.Results Following terlipressin administration,serum sodium level decreased from (136.9 1±4.11) mmol/L to (127.59±10.01) mmol/L (P＜0.001).Sixteen patients (50.0％) didn't have a decrease in serum sodium during treatment;4 (12.5％) patients had a decrease in serum sodium ＞5 mmol/L and ≤10 mmol/L during treatment;12 (37.5％) patients had a decrease greater than 10 mmol/L.In the three groups,serum sodium decreased from (135.00±3.98),(138.50±3.11),(138.91±3.55) mmol/L to (134.06±4.12),(131.25±4.03),(117.75±9.14) mmol/L,respectively.The reduction in serum sodium was related to serum creatinine,model for end-stage liver disease (MELD) score,baseline serum sodium and total dose of terlipressin.Logistic regression analysis showed that the baseline serum sodium [odds ratio (OR)=1.797,95％ confidence interval (CI) 1.079-2.992,P=-0.02] and total dose of terlipressin (OR=1.105,95％CI 1.003-1.218,P=0.04)were the risk factors of hyponatremia.Conclusions Terlipressin caused hyponatremia are not uncommon.Patients with normal serum creatinine,low MELD,high baseline serum sodium and large dose of terlipressin had higher risk of hyponatremia.关键词
特利加压素/低钠血症/肝硬化Key words
Terlipressin/Hyponatremia/Cirrhosis分类
医药卫生引用本文复制引用
周郁芬,忻笑容,谢玲,俞骁珺,谷雷雷,陈平,袁晓琴,许兰涛,吴云林..特利加压素治疗发生低钠血症的危险因素分析[J].内科理论与实践,2017,12(6):375-379,5.
