内科理论与实践2017，Vol.12Issue(6)：386-390,5.DOI:10.16138/j.1673-6087.2017.06.005
卵泡抑素样蛋白1与糖尿病动脉粥样硬化的炎症反应
Follistatin-like 1 and inflammatory responses of diabetic atherosclerosis
摘要
Abstract
Objective To investigate the mechanism of the cytokine follistatin-like 1(FSTL1) in regulating macrophages to promote plaque formation in diabetic atherosclerosis.Methods To detect the expression level of FSTL1 in serum of patients with atherosclerosis and diabetic atherosclerosis by enzyme-linked immunosorbent assay(ELISA).A diabetic mouse model was established and detect the positive area of FSTL1 expression immunohistochemically.The levels of inflammatory cytokines in human macrophages were detected by ELISA after stimulating human macrophages by using oxidized low density lipoprotein (oxLDL) or/and FSTL1,and the mechanism of FSTL1 in the development of diabetic atherosclerosis was explored.Results The expression of cytokine FSTL1 was abnormally elevated in diabetic atherosclerosis than in atherosclerosis [(13.60±4.20) μg/L vs (9.90±3.50) μg/L (P＜0.01)],and it was mainly located in macrophages.FSTL1 stimulated the release of inflammatory cytokines in macrophages and triggered local inflammatory responses.Conclusions The cytokine FSTL1 may be involved in plaque progression in diabetic atherosclerosis through activating inflammatory responses in macrophages.关键词
卵泡抑素样蛋白1/巨噬细胞/糖尿病/动脉粥样硬化Key words
Follistatin-like1/Macrophage/Diabetic/Atherosclerosis分类
医药卫生引用本文复制引用
宋倩,王燕萍,吴舒窈,陈媛媛,曹丽娟,查晴,杨克,刘艳..卵泡抑素样蛋白1与糖尿病动脉粥样硬化的炎症反应[J].内科理论与实践,2017,12(6):386-390,5.基金项目
国家自然科学基金项目(项目编号:81470547) （项目编号:81470547）
上海市科学技术委员会科研计划项目(项目编号:15ZR1426100) （项目编号:15ZR1426100）
