内科理论与实践2017，Vol.12Issue(6)：391-394,4.DOI:10.16138/j.1673-6087.2017.06.006
血清降钙素原水平对急性心肌梗死患者预后的判断价值
Predictive value of serum procalcitonin level for prognosis of acute myocardial infarction
摘要
Abstract
Objective To investigate the association between serum procalcitonin (PCT) level and short-term clinical outcome in patients with acute myocardial infarction (AMI).Methods One hundred and forty-six patients were enrolled,serum PCT,brain natriuretic peptide(BNP),C-reactive protein(CRP) and cardiac troponin Ⅰ (cTnI) were detected within 24 hours.Patients were divided into surviving group and death group according to the 30-day survival outcome.The receiver operating characteristic curve (ROC) and Kaplan-Meier survival curves were plotted.The independent risk factors for predicting death were detected by Cox regression analysis.Results There were 109 cases in surviving group,37 cases in death group.Significant difference in serum PCT level was found between survival group and death group(P＜0.001).ROC curve analysis showed that the area under the curve (AUC) of PCT was 0.869,larger than BNP (0.813),CRP (0.763) and cTnI (0.682);when PCT＞0.2 μg/L,the sensitivity of predicting 30-day mortality was 83.8％,and the specificity was 81.7％.Cox regression analysis showed that PCT was the risk factor for predicting 30-day mortality of AMI [hazard ratio (HR)=1.192,95％ confidence interval(CI):1.106-1.278,P=0.041].Conclusions PCT represented a reliable prognostic marker for 30-day mortality of AMI patients.关键词
心肌梗死/降钙素原/脑钠肽/心肌肌钙蛋白Ⅰ/炎症/预后Key words
Myocardial infarction/Procalcitonin/Brain natriuretic peptide/Cardiac troponin Ⅰ/Inflammation/Prognosis分类
医药卫生引用本文复制引用
于洋,吉律,王海嵘,费爱华..血清降钙素原水平对急性心肌梗死患者预后的判断价值[J].内科理论与实践,2017,12(6):391-394,4.基金项目
上海市科学技术委员会科研计划项目(项目编号:17695840300) （项目编号:17695840300）
