同济大学学报（医学版）2017，Vol.38Issue(6)：6-11,6.DOI:10.16118/j.1008-0392.2017.06.002
强心方组分对心肌梗死后心力衰竭小鼠心功能的影响
Effects of main components of Chinese medicine Qiangxin decoction on cardiac function in mice with myocardial infarction
摘要
Abstract
Objective To investigate the protective effect of the main components of Chinese medicine Qiangxin decoction astragalus membranaceus,aconite and semen lepidii on heart function in mice with myocardial infarction.Methods The acute myocardial infarction model was established in mice and the sham operation was performed in sham group.After AMI was induced,the mice were administrated by gavage with PBS (Sham group),Astragalus (HQ group),Aconite (FZ group),Semen lepidii (TLZ group),1/3 dose of mix components (Mix group) and whole dose mixed components (Mix-full group).After 30 days of administration,the effects on cardiac function in various groups were observed and compared.Results After 30 days of administration,cardiac ultrasonography result showed that the cardiac function of the mice in administration groups was improved (P ＜ 0.05).The results of Immunohistochemistry showed that the myocardial infarct size in administration groups was significantly decreased,and the degree of ventricular remodeling was significantly ameliorated (P ＜ 0.05).Immunofluorescence staining showed that the hypertrophy was ameliorated (P ＜ 0.05).The cardiac protect effect of 1/3 dose mixed administration group was better than that of whole dose mixed administration group.Conclusion The main components of Qiangxin Decoction Astragalus membranaceus,Aconite and Semen lepidii significantly can improve the cardiac function,improve left ventricular remodeling and reduce myocardial fibrosis and myocardial hypertrophy after myocardial infarction in mice.关键词
急性心肌梗死/心力衰竭/黄芪/附子/葶苈子/心肌肥大/心肌纤维化/小鼠Key words
acute myocardial infarction/heart failure/astragalus membranaceus/aconite/semen lepidii/myocardial hypertrophy/myocardial fibrosis/mice分类
医药卫生引用本文复制引用
宝璐尔,张林,周晓慧,孟庆姝,刘中民,范慧敏..强心方组分对心肌梗死后心力衰竭小鼠心功能的影响[J].同济大学学报（医学版）,2017,38(6):6-11,6.基金项目
国家自然科学基金(81470472、81670234、81470393) （81470472、81670234、81470393）
上海市进一步加快中医药事业发展三年行动计划(ZY3-LCPT-2-1003) （ZY3-LCPT-2-1003）
上海市医学重点专科建设计划(ZK2012A27) （ZK2012A27）
上海领军人才培养计划(2012-053) （2012-053）
上海市浦东新区卫生系统领先人才培养计划(PKR2011-01) （PKR2011-01）
上海市卫生和计划生育委员会项目(2014ZYJB0502,ZY3-LCPT-2-1003) （2014ZYJB0502,ZY3-LCPT-2-1003）
上海市浦东新区卫生和计划生育委员会项目(PW2013E-1) （PW2013E-1）
