同济大学学报（医学版）2017，Vol.38Issue(6)：23-26,4.DOI:10.16118/j.1008-0392.2017.06.005
MicroRNA-133a在复发性肝细胞癌中差异表达及临床病理意义
Expression of microRNA-133a in recurrent hepatocellular carcinoma and its relationship with clinicopathological parameters
摘要
Abstract
Objective To investigate the expression of microRNA-133a (miR-133a) in recurrent hepatocellular carcinoma and its relationship with clinicopathological parameters.Methods Clinical and pathological data of 118 patients with hepatocellular carcinoma were enrolled in the study,including 44 cases of short-term recurrence (＜ 2 y) and 74 cases of long-term recurrence (＞ 2 y).The expression of miR-133a in liver cancer tissue was detected by real-time fluorescence quantitative PCR.The relationship between miR-133a expression and clinicopathological parameters was analyzed.Results The relative expression of miR-133a in short-term recurrence group was significantly higher than that in long-term recurrence group.The expression of miR-133a was correlated HBV DNA,microvascular invasion,satellite focus and T stage,but not correlated with age,sex,HBsAg,HBeAg,serum AFP,total bilirubin,albumin,ALT,AST,prothrombin time,number of tumors,tumor size,pathologic stage,histological type,tumor location,liver cirrhosis,tumor capsule,and postoperative interventional therapy.Conclusion The expression of miR-133a is associated with the short-term recurrence,indicating that it can serve as a molecular marker for prognosis of patients with hepatocellular carcinoma.关键词
miR-133a/肝细胞癌/复发/临床病理参数Key words
miR-133a/hepatocellular carcinoma/recurrence/clinicopathological parameters分类
医药卫生引用本文复制引用
谷晓媛,陆新元,张为强..MicroRNA-133a在复发性肝细胞癌中差异表达及临床病理意义[J].同济大学学报（医学版）,2017,38(6):23-26,4.基金项目
国家自然科学基金青年项目(81602603) （81602603）
上海市卫生和计划生育委员会项目(20144Y0047) （20144Y0047）
