同济大学学报（医学版）2017，Vol.38Issue(6)：37-40,4.DOI:10.16118/j.1008-0392.2017.06.008
COPD急性发作期患者外周血IL-35、hs-CRP检测及临床意义
Serum IL-35 and hs-CRP levels in COPD patients with acute exacerbation and their clinical significance
摘要
Abstract
Objective To investigate serum IL-35 and hs-CRP level in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD),and their clinical significance.Methods Eighty patients with COPD,including 49 cases of acute exacerbation (group A) and 31 cases of stable disease (group B),and 25 healthy subjects (group C) were recruited in the study.Serum levels of IL-35 and hs-CRP were determined by ELISA.Results Compared to control group [(5.194 ± 1.595)ng/ml],serum IL-35 levels in group B and A were significantly lower [(4.171 ± 1.339) ng/ml and (3.480 ± 1.790) ng/ml;P ＜ 0.05],while there was no significant difference between group B and group A (P ＞ 0.05).Serum Hs-CRP levels in group A were significantly higher than those in group B and group C (61.143 ± 30.024 mg/L vs.12.161 ± 4.495 mg/L and 1.075 ±0.855 mg/L,P ＜ 0.05).The serum IL-35 was negatively correlated with hs-CRP (r =-0.349,P =0.014) in group A,but not in group B (r =-0.237,P =0.199).Conclusion The low serum IL-35 level and high hs-CRP level in AECOPD patients may be used as an indicator for clinical diagnosis.关键词
慢性阻塞性肺疾病/白细胞介素35/超敏CRPKey words
chronic obstructive pulmonary disease/IL-35/hs-CRP分类
医药卫生引用本文复制引用
李红强,姜晓萍,董天操,孙冰珂,郑贵珍,白建文..COPD急性发作期患者外周血IL-35、hs-CRP检测及临床意义[J].同济大学学报（医学版）,2017,38(6):37-40,4.基金项目
上海市浦东新区卫生和计划生育委员会卫生科技项目(PW2014D-9) （PW2014D-9）
