世界中医药2018，Vol.13Issue(1)：142-145,4.DOI:10.3969/j.issn.1673-7202.2018.01.036
沙棘果渣总黄酮的降血脂及降血糖作用
Hypolipidemic and Hypoglycemic Effects of Total Flavonoids from Pomace of Fructus Hippophae
摘要
Abstract
Objective:To study the hypolipidemic and hypoglycemic effects of total flavonoids from pomace of Fructus Hippophae.Methods:A total of 72 Kunming male mice were randomly divided into six groups (n =12 in each group):normal group,model group,simvastatin group,low-dose flavonoid group,middle-dose flavonoid group and high-dose flavonoid group.Except the blank control group,the mice were fed with high fat diets to induce hyperlipidemia.The body weight of mice was measured every day,and the dose was adjusted according to the weight.On the 40th day,the mice were decapitated and the TC,TG,HDL-C and LDL-C were detected.Changes of weight and viscera indexes were observed.The hypoglycemic activity of polysaccharide was investigated by animal experiments.Results:Compared with model group,the TC,TG and LDL-C of serum in the flavonoid groups were deceased significantly (P ＜ 0.05) and HDL-C was increased significantly (P ＜ 0.05).The total flavonoids from pomace of Fructus Hippophae group decreased fasting blood glucose values significantly (P ＜ 0.05).Conclusion:The total flavonoids from pomace of Fructus Hippophae have hypolipidemic and hypoglycemic effects.关键词
沙棘果渣总黄酮/降血脂作用/降血糖作用Key words
Total flavonoids from pomace of Fructus Hippophae/Hypolipidemic effects/Hypoglycemic effects分类
医药卫生引用本文复制引用
孙琛,冯野,谢培,宋忠兴,唐志书..沙棘果渣总黄酮的降血脂及降血糖作用[J].世界中医药,2018,13(1):142-145,4.基金项目
陕西省科技厅社会发展科技攻关项目(2015SF244)——利用沙棘果渣开发沙酮降脂胶囊研究 （2015SF244）
