陕西医学杂志2018，Vol.47Issue(2)：215-218,4.DOI:10.3969/j.issn.1000-7377.2018.02.025
早产儿脑白质损伤影像学特征及危险因素研究
Imaging features and risk factors of white matter damage in premature infants
摘要
Abstract
Objective:To explore the imaging features and related risk factors of white matter damage in premature infants.Methods:214 cases of premature infants were selected as research subjects,among them 126 cases of premature in-fants with white matter damage were as observe group,88 cases of normal preterm infants as control group,all preterm in-fants were examined by nuclear magnetic resonance spectrometer,admission and examination results of two groups were compared between the groups;gestational age,birth method,mechanical ventilation and so on were used to single factor a-nalysis.The significant factors in the single factor analysis were analysised by multivariate Logistic regression.Results:There was no significant difference in the gender,Apgar score,gestational hypertension or diabetes between the two groups (P>0.05),gestational age,mode of delivery,blood glucose,myocardial enzymes,CRP,albumin,low temperature,infection after birth,asphyxia were significantly different between the two groups(P<0.05).In 126 cases of brain white matter inju-ry,there were 103 cases of local lesions,T1 weighted showed high signal or no significant change,T2 weighted low signal;23 cases were diffuse lesions,the signal of diffusion weighted imaging(DWI)was high signal,there was no significant changes in the signal with T1-weighted or T2-weighted.There was no significant changes in the signal with magnetic resonance ima-ging(MRI),Among them,the white matter damage of I grade was 48 cases,II grade was 41 cases,III grade was 37 cases after baby was borth two weeks.Single factor analysis showed that there was significant difference in the infection after birth,gestational age and CRP level in the degree of white matter injury(P<0.05),Logistic multiple regression analysis showed that gestational age and postnatal infection were the risk factors for severe brain white matter damage(P<0.05). Conclusion:The white matter damage in premature infants can be detect by DWI,the risk of white matter damage is high in the low gestational age and infection after birth.关键词
早产儿/脑白质损伤/磁共振成像/弥散加权成像/危险因素Key words
Premature infant/Brain white matter injury/Magnetic resonance imaging/Diffusion weighted imaging Risk factors分类
医药卫生引用本文复制引用
张洪涛,李扬,寇晓娜,王利顺..早产儿脑白质损伤影像学特征及危险因素研究[J].陕西医学杂志,2018,47(2):215-218,4.基金项目
河北省秦皇岛市科学技术局项目(201602A054) （201602A054）
