摘要
Abstract
Objective:To investigate the changes of adiponectin levels in serum and gingival crevicular fluid be-fore and after basic treatment for chronic periodontitis and the clinical significance.Methods:36 cases of patients with chronic periodontitis(the observation group)treated in our hospital and 36 healthy volunteers(the healthy group)who underwent oral examinations in our hospital during the same period were enrolled in the study,and the observation group were given basic treatment.Changes in adiponectin levels in serum and gingival crevicular fluid, inflammatory factors[interleukin-6(IL-6),interleukin-8(IL-8)]and clinical indicators[periodontal probing depth (PD),clinical attachment loss(AL),bleeding index(BI)]were compared between the two groups before and after treatment,and the clinical significance of the changes was explored.Results:The adiponectin levels in serum and gin-gival crevicular fluid of the observation group before treatment were significantly lower than those in the same group after treatment and those in the healthy group(P<0.05).The levels of IL-6 and IL-8 in the observation group be-fore and after treatment were significantly higher than those in the healthy group(P<0.05).The PD,AL and BI in the observation group after treatment were significantly smaller than those before the treatment(P<0.05).Sper-man correlation analysis showed that adiponectin levels in patients with chronic periodontitis were negatively correla-ted with inflammatory factors IL-6 and IL-8 in serum and gingival crevicular fluid(r1=-0.758,r2=-0.698,P<0. 05),while the PD and AL were positively correlated with IL-6 and IL-8 in serum and gingival crevicular fluid(r3=0. 558,r4=0.598,r5=0.698,r6=0.601,all P<0.05).Conclusion:There is a certain correlation between the inci-dence and progression of chronic periodontitis and adiponectin levels,and its pathogenesis may be related to the de-crease of inflammatory factors by adiponectin.关键词
牙周炎/脂联素/白细胞介素-6/白细胞介素-8/因果律Key words
Periodontitis/Adiponectin/Interleukin-6/Interleukin-8/Causality分类
医药卫生
