天津工业大学学报2018，Vol.37Issue(1)：7-12,6.DOI:10.3969/j.issn.1671-024x.2018.01.002
分离膜在转移因子生产中的应用
Application of separation membrane in transfer factor production
摘要
Abstract
In order to improve transfer factor production efficiency, this paper used tube microfiltration and ultrafiltration device instead of dialysis bag to extract transfer factor from pig spleen.Dilution methods of pig spleen homoge-neous solution, freezing and thawing times and membrane permeate rate recovery were studied in separation membrane process.Results showed that it is better which spleen homogeneous solution was freeze-thawed three times,and diluted 1:1(V:V)with pure water combined continuous pure water addition.Microfiltration and ultrafiltration operation can be completed in about 3 h.Operating temperature was always lower than 37℃which was suitable for maintenance of transfer factor activity.And the concentration of peptide and ribose in UF perme-ate liquid also meet requirements of semi-finished products.So because of simple operation,low cost and short production cycle,membrane process can be applied to large-scale industrial production.关键词
分离膜/转移因子/管式膜/微滤/超滤Key words
separation membrane/transfer factor/tubular membrane/microfiltration/ultrafiltration分类
轻工纺织引用本文复制引用
曹占平,宋晓绪,范云双,王尚尚,苏建东,刘恩华..分离膜在转移因子生产中的应用[J].天津工业大学学报,2018,37(1):7-12,6.基金项目
天津市海洋经济创新发展区域示范项目(CXSF2014-24) （CXSF2014-24）
