畜牧兽医学报2018，Vol.49Issue(1)：10-17,8.DOI:10.11843/j.issn.0366-6964.2018.01.002
噁唑烷酮—喹诺酮杂合物的研究进展
Advances on Oxazolidinone-quinolone Hybrids
摘要
Abstract
Due to the increasing severity of bacterial drug resistance,the demand for novel antimicrobial agents has been growing in recent years.The multi-target hybrid which combines two kinds of drugs by a certain way provides the possibility for expanding the antibacterial spectrum,enhancing the activity against drug-resistant bacteria and reducing the frequency of bacterial resistance,and has become a new strategy to the research and development of novel antimicrobial agents.Meanwhile,oxazolidinones and quinolones with their unique mechanism ot action and the complementary antibacterial spectrum attract the attention of researchers.Oxazolidinone-quinolone hybrids incorporating oxazolidinone and quinolone pharmacophores have been synthesized and shown to be active against a variety of susceptible and resistant Gram-positive and Gram-negative bacteria.In the present paper,the design,synthesis and antimicrobial activities of oxazolidinonequinolone hybrids,and the research progress of cadazolid,a oxazolidinone-quinolone hybrid which is currently at the stage of clinical trials,are reviewed.关键词
噁唑烷酮/喹诺酮/噁唑烷酮—喹诺酮杂合物/抗菌活性/咔哒唑胺Key words
oxazolidinone/quinolone/oxazolidinone-quinolone hybrids/anti-bacterial activities/cadazolid分类
医药卫生引用本文复制引用
刘利利,张继瑜..噁唑烷酮—喹诺酮杂合物的研究进展[J].畜牧兽医学报,2018,49(1):10-17,8.基金项目
国家科技支撑计划项目(2015BAD1101) （2015BAD1101）
国家现代农业产业技术体系专项(CAR-38) （CAR-38）
