西南国防医药2018，Vol.28Issue(2)：123-126,4.DOI:10.3969/j.issn.1004-0188.2018.02.008
别嘌呤醇对高龄不稳定型心绞痛并高尿酸血症的疗效分析
An analysis on efficacy of allopurinol in treatment of patients with senile unstable angina pectoris and hyperuricemia
毛璟怡1
作者信息
- 1. 614000四川乐山,乐山市人民医院老年病科
- 折叠
摘要
Abstract
Objective To analyze the therapeutic effect of allopurinol in the treatment of patients with senile unstable angina pectoris (UAP) complicated with hyperuricemia.Methods A total of 87 patients with senile UAP and hyperuricemia were randomized to a treatment group (n=44) and a control group (n=43);the control group received routine treatment,and based on this,the treatment group was additionally treated with allopurinol;the changes in the angina pectoris degree,the level of blood uric acid,the level of high-sensitive C-reactive protein (hs-CRP),and the exercise tolerance and adverse reactions before and after the treatment were compared between the two groups.Results Three months after the treatment,the angina pectoris degree in the treatment group was significantly lower than that in the control group (P ＜ 0.05),and the levels of blood uric acid and hs-CRP were also significantly lower than those in the control group (P ＜ 0.05),while the maximum ST depression,the maximum heart rate and the duration from start to end of exercise were significantly higher or longer than those in the control group (P ＜ 0.05).There was no statistically significant difference in the incidence of adverse reactions between two groups (P ＞ 0.05).Conclusion Allopurinol can significantly relieve the symptom of angina pectoris of patients with senile UAP complicated with hyperuricemia,obviously reduce the levels of hs-CRP and blood uric acid and safely and remarkably improve the exercise tolerance of patients.关键词
不稳定型心绞痛/高尿酸血症/别嘌呤醇/疗效Key words
unstable angina pectoris/hyperuricemia/allopurinol/efficacy分类
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毛璟怡..别嘌呤醇对高龄不稳定型心绞痛并高尿酸血症的疗效分析[J].西南国防医药,2018,28(2):123-126,4.
