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首页|期刊导航|药物分析学报(英文)|A liquid chromatography with tandem mass spectrometry method for quantitating total and unbound ceritinib in patient plasma and brain tumor

A liquid chromatography with tandem mass spectrometry method for quantitating total and unbound ceritinib in patient plasma and brain tumor

Xun Bao Jianmei Wu Nader Sanai Jing Li

药物分析学报(英文)2018,Vol.8Issue(1):20-26,7.
药物分析学报(英文)2018,Vol.8Issue(1):20-26,7.

A liquid chromatography with tandem mass spectrometry method for quantitating total and unbound ceritinib in patient plasma and brain tumor

A liquid chromatography with tandem mass spectrometry method for quantitating total and unbound ceritinib in patient plasma and brain tumor

Xun Bao 1Jianmei Wu 1Nader Sanai 2Jing Li1

作者信息

  • 1. Karmanos Cancer Institute,Wayne State University,Detroit,MI 48201,USA
  • 2. Barrow Neurological Institute,St.Joseph's Hospital & Medical Center,Phoenix,AZ 85013,USA
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摘要

关键词

Ceritinib/Reversed-phase liquid chromatography with tandem mass spectrometry(LC–MS/MS)/Fraction unbound in plasma/Fraction unbound in brain tissue/Brain tumor penetration/Unbound brain-to-plasma partition coefficient

Key words

Ceritinib/Reversed-phase liquid chromatography with tandem mass spectrometry(LC–MS/MS)/Fraction unbound in plasma/Fraction unbound in brain tissue/Brain tumor penetration/Unbound brain-to-plasma partition coefficient

引用本文复制引用

Xun Bao,Jianmei Wu,Nader Sanai,Jing Li..A liquid chromatography with tandem mass spectrometry method for quantitating total and unbound ceritinib in patient plasma and brain tumor[J].药物分析学报(英文),2018,8(1):20-26,7.

基金项目

This study was supported by the United States Public Health Service Cancer Center Support Grant P30 CA022453. We thank Novartis for providing the study drug and isotope-labeled internal standard and providing financial support for the clinical study. We particularly thank the patients enrolled in the study. ()

药物分析学报(英文)

OASCI

2095-1779

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