中国动脉硬化杂志2018，Vol.26Issue(2)：165-170,6.
维持性血液透析患者心外膜脂肪组织与冠状动脉钙化、趋化素的关系
Association of epicardial adipose tissue with coronary artery calcification and chemerin in maintenance hemodialysis patients
摘要
Abstract
Aim To explore association of epicardial adipose tissue (EAT) with coronary artery calcification and chemerin in maintenance hemodialysis (MHD) patients.Methods 90 MHD patients in Tianjin Fifth Central Hospital were included in the study.MHD patients were divided into low-risk (＜ 10％),mid-risk (10％～ 20％) and high-risk group (＞20％) according to Framingham risk score (FRS).60 normal subjects were selected as control group.Serum chemerin,C-reactive protein (CRP),blood routine and biochemistry were determined,multi-slice spinal CT examination were underwent.The EAT volume and coronary artery calcium score (CACS) were calculated with the Philips workstation.The relationship of EAT volume with CACS,serum chemerin,CRP,FRS were analyzed.Results Serum chemerin,CRP and neutrophil to lymphocyte ratio were significantly higher in MHD group compared to control group (all P＜0.01).EAT volume,CACS and serum chemerin were significantly higher in high-risk group and in mid-risk group compared to those in low-risk group (P＜0.05 or P＜0.01),EAT volume,serum chemerin were significantly higher in highrisk group compared to those in mid-risk group (all P＜0.05).The multivariate linear stepwise regression showed that CACS,serum chemerin,CRP,FRS were the influencing factors of EAT(P＜0.05 or P＜0.01).Conclusion Serum chemerin,CRP and neutrophil to lymphocyte ratio were significantly higher in MHD patients.There was microinflammation in MHD patients.In MHD patients,EAT volume,CACS and serum chemerin in high-risk group and in midrisk group were both higher than those in low-risk group.CACS,serum chemerin,FRS were correlated with EAT volume.EAT might be used as predictors of cardiovascular risk in MHD patients.关键词
维持性血液透析/心外膜脂肪组织/冠状动脉钙化/趋化素/Framingham危险评分Key words
Maintenance hemodialysis/Epicardial adipose tissue/Coronary artery calcification/Chemerin/Framingham risk score分类
医药卫生引用本文复制引用
朱慧敏,王东红,师军华,孔海霞,李又洁,李洪娟,王明超,张焕荣..维持性血液透析患者心外膜脂肪组织与冠状动脉钙化、趋化素的关系[J].中国动脉硬化杂志,2018,26(2):165-170,6.基金项目
天津市滨海新区塘沽科技兴区项目(2012XQ15-09) （2012XQ15-09）
