中国动脉硬化杂志2018，Vol.26Issue(2)：201-206,6.
动脉粥样硬化中巨噬细胞介导胞葬作用的研究进展
The research progress on macrophage mediated efferocytosis in atherosclerosis
摘要
Abstract
The accumulation of a large number of apoptotic and necrotic cells in atherosclerotic plaques is the main cause of plaque enlargement,necrotic core formation and plaque rupture.Apoptotic cells are engulfed and cleared quickly by macrophage and other phagocytes mediated efferocytosis in physiological state.However,recent studies have shown that the clearance rate of apoptotic cells in plaque is far lower than that in physiological state,and its mechanism is closely related to macrophage mediated efferocytosis dysfunction.This review summarizes the research progress of macrophage mediated efferocytosis and its functional defects in atherosclerosis,and hopes to provide theoretical and experimental basis for prevention and treatment of atherosclerotic cardiovascular disease.关键词
动脉粥样硬化/胞葬作用/巨噬细胞/凋亡Key words
Atherosclerosis/Efferocytosis/Macrophage/Apoptosis分类
医药卫生引用本文复制引用
廖思聪,于杨,王大新,秦树存..动脉粥样硬化中巨噬细胞介导胞葬作用的研究进展[J].中国动脉硬化杂志,2018,26(2):201-206,6.基金项目
国家自然科学基金重大研究计划培育项目(91539114) （91539114）
山东省泰山学者岗专项基金项目(ts201511057) （ts201511057）
国家重大项目973计划项目(2007CB936104) （2007CB936104）
