中国感染控制杂志2018，Vol.17Issue(1)：36-40,5.DOI:10.3969/j.issn.1671-9638.2018.01.008
GM试验联合CD4+T淋巴细胞诊断艾滋病患者侵袭性曲霉病的研究
Galactomannan test combined with CD4+T lymphocytes for the diagnosis of invasive aspergillosis in patients with AIDS
摘要
Abstract
Objective To evaluate the effect of galactomannan(GM) test combined with CD4+ T lymphocyte detection on early diagnosis of invasive aspergillosis (IA) in patients with acquired immunodeficiency syndrome (AIDS).Methods 197 AIDS patients who were suspected with IA in a hospital from January 2014 to December 2016 were analyzed retrospectively,they were divided into confirmed IA group (n =35),clinically diagnosed IA group (n=96,suspected cases),and non-IA group(n =66),sensitivity and specificity of GM test and GM test combined CD4+ T lymphocyte counting for diagnosing IA were compared.Results In confirmed IA group,clinically diagnosed IA group,and non-IA group,the medium values of GM (minimum,maximum) were 1.29(0.65,1.84)pg /mL,0.91(0.36,1.23)pg /mL,and 0.11(0.28,0.72)pg /mL respectively,CD4+ T lymphocyte counting were 45 (29,69)cells/μL,79(35,99) cells/μL,and 89 (59,158) cells/μL respectively,GM value and CD4+ T lymphocyte counting among three groups were significantly different(all P＜0.05).The sensitivity and specificity of single GM test for diagnosing IA in AIDS patients were 64.9％ and 72.7％ respectively;sensitivity and specificity of two consecutive GM test within one week for diagnosing IA were 72.5 ％ and 95.5 ％ respectively;sensitivity and specificity of GM test combined CD4+ T lymphocyte counting were 86.3％ and 90.9％ respectively.Conclusion GM test has better diagnostic value for IA in AIDS patients,continuous GM test and GM test combined CD4+ T lymphocyte counting will further improve the clinical diagnostic value for IA.关键词
半乳甘露聚糖/CD4+ T淋巴细胞/艾滋病/侵袭性曲霉菌病Key words
galactomannan/CD4+ T lymphocyte/acquired immunodeficiency syndrome/invasive aspergillosis分类
医药卫生引用本文复制引用
柳明波,方霞,梁欣,李锡燕..GM试验联合CD4+T淋巴细胞诊断艾滋病患者侵袭性曲霉病的研究[J].中国感染控制杂志,2018,17(1):36-40,5.基金项目
广西壮族自治区卫生厅自筹青年基金(Z2013746) （Z2013746）
广西医科大学青年科学基金(GXMUYSF201347) （GXMUYSF201347）
