中国感染控制杂志2018，Vol.17Issue(1)：52-55,4.DOI:10.3969/j.issn.1671-9638.2018.01.011
新方法初治结核性胸膜炎的疗效观察
Efficacy of a new therapeutic approach as initial treatment for tuberculous pleuritis
摘要
Abstract
Objective To explore the therapeutic efficacy of levofloxacin combined with anti-tuberculosis drugs and thoracic catheterization for the treatment of tuberculous pleuritis.Methods Patients who were admitted to Departments of Infectious Diseases of Hanzhong Central Hospital and Ankang Central Hospital between February 2014 and August 2016 for initial treatment of tuberculous pleuritis were included in the study,they were divided into groups A,B,C and D.Group A received 2HRZE + 7HR regimen combined with conventional drainage;group B received 2HRZE+ 7HR regimen combined with thoracic catheterization;group C received 2HRZEV + 7HR regimen combined with thoracic catheterization;group D received 2HRZEV + 10HR regimen combined with thoracic catheterization.groups B,C and D received thoracic catheterization,normal saline 20mL and urokinase 100,000U were given through the drainage tube.Results A total of 172 patients with newly diagnosed tuberctlous pleurisy were received for treatment.There were 45,53,38,and 36 cases in group A,B,C,and D respectively.The total effective rate of therapy for pleural effusion in group A was lower than that in group B(64.44％ vs 90.57％,x2 =9.863,P＜ 0.05);after two month therapy,total effective rate of therapy for pleural effusion in group B was lower than that in group C (18.87％ vs 39.47％,x2 =4.716,P＜0.05);at the end of therapy,total effective rate in group C was lower than that in group D (60.53 ％ vs 83.33 ％,x2 =4.731,P＜0.05).Conclusion For initial treatment of patients with tuberculous pleuritis,2HRZEV + 10HR antituberculosis regimen combined with thoracic catheterization and urokinase infusion can significantly improve the clinical symptoms and recovery rate of tuberculous pleuritis,facilitate drainage of pleural effusion and prevent pleural thickening,adhesion and encapsulation.关键词
初治结核性胸膜炎/左氧氟沙星/胸腔置管/尿激酶Key words
initial treatment for tuberculous pleuritis/levofloxacin/thoracic catheterization/urokinase分类
医药卫生引用本文复制引用
唐先梅,赵英仁,江自成,张庆,龙芳,金红梅..新方法初治结核性胸膜炎的疗效观察[J].中国感染控制杂志,2018,17(1):52-55,4.基金项目
汉中市科研项目(9162016Y0897) （9162016Y0897）
