摘要
Abstract
Objective To evaluate the distribution and antimicrobial resistance of pathogens in neonates.Methods Blood culture specimens from hospitalized neonates in the neonatal intensive care unit (NICU) of a maternal and child heath hospital between January 1,2013 and December 31,2015 were investigated retrospectively,blood culture and antimicrobial susceptibility testing results were analyzed with WHONET 5.6 software.Results A total of 255 strains were isolated from blood culture specimens,including 219 strains(85.88 ％) of gram-negative bacteria,29 strains(11.37％) of gram-positive bacteria,and 7 strains(2.75％) of fungi.The isolated bacteria were mainly Klebsiella pneumoniae (n =157),Escherichia coli (n =35),and Streptococcus B (n =13).Resistance of Escherichia coli to ampicillin and piperacillin were 97.14％ and 94.29％ respectively,all were sensitive to cefoxitin,imipenem,meropenem,ertapenem,and amikacin.Resistance rates of Klebsiella pneumoniae to piperacillin,cefazolin,and cefuroxime were 93.63％,87.90％,and 85.35 ％ respectively,but was sensitive to amikacin.Resistance rates of the main gram-negative bacteria to enzyme inhibitor (amoxicillin/clavulanic acid,ticarcillin/clavulanic acid),cephalosporins (ceftazidime,cefoxitin),and sulfonamides (sulfamethoxazole compound) increased,difference were all statistically significant (all P＜0.01).Conclusion Klebsiella pneumoniae and Escherichia coli are the major pathogens causing bloodstream infection in NICU,and resistance rates to a multiple antimicrobial agents are high,empirical medication for anti infection treatment should be combined with local data.关键词
新生儿/血培养/病原菌/耐药性/抗药性,微生物Key words
neonate/blood culture/pathogen/drug resistance/microbial分类
医药卫生
