中国临床医学2017，Vol.24Issue(6)：863-867,5.DOI:10.12025/j.issn.1008-6358.2017.20170052
可穿戴设备数字化评估多巴丝肼对不同站姿条件下帕金森病患者平衡稳定性的影响
Effect of levodopa and benserazide hydrochloride on static balance stability of patients with Parkinson disease under different standing positions: digital evaluation methods with wearable device
摘要
Abstract
Objective:To evaluate the effect of levodopa and benserazide hydrochloride on static balance stability patients with of Parkinson disease (PD) by using wearable device.Methods:PD patients with Hoehn & Yahr stage of grade 3 were enrolled and age-matched healthy subjects were selected as control group.The balance stability data under different positions,including natural standing with open eyes,standing on the feet with open eyes and natural standing with close eyes,were recorded by wearable sensor in ON and OFF state of drug.The swing displacements of antero-posterior/medio-lateral (the center of gravity swing parameters) under different standing positions were compared between two groups.Results:Totally 12 PD patients with Hoehn & Yahr stage of grade 3 and 12 healthy subjects were selected.The age,gender,and score of Montreal cognitive assessment (MoCA) were not significantly different between two groups.In control group,the swing displacement under position of natural standing with open eyes was significantly less than that under position of natural standing with close eyes (P＜0.05).In PD group,the swing displacement was not significantly changed in ON and OFF stage of drug.However,under position of natural standing with open eyes,the displacement of antero-posterior swing in PD group was significantly less than that in control group in OFF state of the drug (P＜0.05);under naturally standing state with close eyes,the displacement of medio-lateral swing in PD group was significantly greater than that in control group (P＜0.05).Conclusions:Digital wearable devices can effectively assess the balance stability of PD patients and healthy people;levodopa and benserazide hydrochloride do not improve the balance capacity of PD patients significantly;PD patients may have abnormal integration of visual and somatosensory.关键词
帕金森病/姿势平衡障碍/可穿戴设备/多巴丝肼Key words
Parkinson disease/static posture balance/wearable device/levodopa and benserazide hydrochloride分类
医药卫生引用本文复制引用
李常青,吴曦,沈林勇,胡小吾,钱晋武..可穿戴设备数字化评估多巴丝肼对不同站姿条件下帕金森病患者平衡稳定性的影响[J].中国临床医学,2017,24(6):863-867,5.基金项目
国家自然科学基金(51275282),教育部博士点基金(20123108110009).Supported by National Natural Science Foundation of China (51275282) and Doctoral Program of the Ministry of Education of China (20123108110009). （51275282）
