中国临床医学2017，Vol.24Issue(6)：884-891,8.DOI:10.12025/j.issn.1008-6358.2017.20170777
孕妇及其新生儿端粒长度的影响因素分析
Influence factors for maternal and neonatal telomere length
摘要
Abstract
Objective:To comprehensively investigate the environmental factors influencing maternal and neonatal telomere length at birth,and to provide evidences for exploring the role of telomere in pathogenesis and development of diseases.Methods:From March 2015 to February 2016,444 newborns and their mothers in Nanjing Drum Tower Hospital were enrolled.Questionnaire surveys,physical examinations and clinical assessments were conducted in pregnant women,and the maternal peripheral blood samples as well as their matching umbilical venous blood samples were collected.The relative telomere length was measured by quantitative PCR method.The maternal telomere length and neonatal telomere length were compared by paired t test.The telomere length between different subgroups was compared by variance analysis and t test.The correlation between maternal telomere length and neonatal telomere length as well as the correlations of telomere length with other continuous variables were analyzed by using general linear model.Results:The overall telomere length of cord blood was significantly longer than that of maternal blood (0.358 vs 0.309,P＜0.001),but there was no significant correlation between telomere length of maternal blood and telomere length of cord blood (r2 =0.004,P=0.174).There was a significant positive correlation between maternal education level and the telomere length of cord blood (P =0.022).There were no obvious correlations of maternal and neonatal telomere length with gestational age,delivery mode,newborn sex and birth weight.The more dairy intake during pregnancy,the shorter maternal telomere length (P=0.048).There were no significant differences of maternal and neonatal telomere length among different subgroups intaking fruits,vegetables,meat,animal offal,fish,shrimp,bean products,baked and preserved food,folic acid and vitamins.Coffee drinking during pregnancy was significantly associated with shorter neonatal telomere length (P=0.011).Second hand smoke exposure,alcohol consumption and tea drinking during pregnancy were not significantly associated with maternal and neonatal telomere lengths.Longer maternal telomere length was observed in those taking physical exercise during pregnancy (P=0.01),but no significant difference was observed in neonatal telomere length (P=0.187).Conclusions:Various environment exposures such as education level,intake of dairy products,coffee drinking and physical exercise during pregnancy have significant effects on maternal and neonatal telomere length.This study provides valuable clues for further revealing the role of telomere in diseases.关键词
端粒缩短/孕妇/胎血/影响因素Key words
telomere shortening/pregnant women/fetal blood/influencing factors分类
医药卫生引用本文复制引用
翁侨,杜江波,俞飞,靳光付,沈洪兵,胡娅莉..孕妇及其新生儿端粒长度的影响因素分析[J].中国临床医学,2017,24(6):884-891,8.基金项目
中央高校基本科研专项资金(021414380319).Supported by the Fundamental Research Funds for the Central Universities(021414380319). （021414380319）
