李峰 1李缨 1王蕾 1沈波 2邹建洲 2高秋凤 1徐炜新3
作者信息
- 1. 上海市嘉定区中心医院肾脏内科,上海201800
- 2. 复旦大学附属中山医院肾脏内科,上海200032
- 3. 上海市嘉定区中心医院检验科,上海201800
- 折叠
摘要
Abstract
Objective:To compare the clearance effect on serum fibroblast growth factor-23 (FGF-23) between traditional hemodialysis (HD) and HD combined with hemoperfusion (HP).Methods:Totally 60 maintenance hemodialysis (MHD) patients from January 2016 to June 2016 in Central Hospital of Jiading District in Shanghai were randomly divided into HD group (30 cases) and HD+HP group (30 cases).The patients in HD group underwent HD (3 times/week,4 h/time),the patients in HD+HP group underwent HD (2 times/week,4 h/time),HD combined with HP (1 time/week,2 h/time) then change into HD for 2 h.The treatment lasted for 6 months.The data of serum phosphorus (P),calcium (Ca),urea nitrogen (BUN),creatinine (Scr),intact parathyroid hormone (iPTH),FGF-23 levels were collected before and after study.Results:There were no significantly differences of BUN,Scr,Ca,P,iPTH,FGF-23 between HD group and HD+ HP group at the beginning of study.After 6 months treatment,the levels of BUN and Scr were significantly decreased (all P＜0.05) in both groups.The levels of P,iPTH,and FGF-23 were significantly decreased after treatment in HD+ HP group (all P＜0.05).The levels of P,iPTH,and FGF-23 in HD+HP group were significantly lower than those in HD group (P＜0.05) at the end of study,and no significantly differences of Hb,Alb,BUN,Scr were found between groups.Conclusions:Compared with HD,HD combined with HP treatment can significantly reduce the levels of P,iPTH,and FGF-23 in serum of MHD patients.关键词
血液透析/血液灌流/成纤维细胞生长因子23Key words
hemodialysis/hemoperfusion/fibroblast growth factor-23分类
医药卫生
