中国临床医学2017，Vol.24Issue(6)：935-938,4.DOI:10.12025/j.issn.1008-6358.2017.20170613
慢性扁桃体炎患者甲状腺自身免疫状态的临床分析
Clinical analysis of autoimmune thyroid disease in patients with chronic tonsillitis
王永森 1张朝赞 1尹静 1戴秀丽 1周丽娜 1顾世民1
作者信息
- 1. 沧州市中心医院体检中心,沧州061001
- 折叠
摘要
Abstract
Objective:To investigate the relationship between chronic tonsillitis and thyroid autoimmunity by detecting thyroid autoantibodies and analyzing the morbidity of autoimmune thyroid diseases (AITD) in patients with recurrent chronic tonsillitis.Methods:122 female patients with chronic tonsillitis (female inflammatory group) and 105 male patients (male inflammatory group) were selected as the research objects.172 female patients (female non-inflammatory group) and 146 male patients (male non-inflammatory group) of the same age and with no chronic tonsillitis were selected as the control group.Retrospective analysis was performed.The differences of the positive rates of thyroid autoantibodies including thyroglobulin antibodies (TgAb),thyroid peroxidase antibodies (TPOAb),and thyrotropin receptor antibody (TRAb) between the two groups were detected and comparatively analyzed.The morbidity of autoimmune thyroid diseases such as chronic lymphocytic thyroiditis (CLT),Graves disease (GD) and other autoimmune diseases was further analyzed and comparatively analyzed between the two groups.The difference of abnormal thyroid function between the two groups was compared.Results:The positive rates of TgAb and TPOAb in male and female inflammatory groups (male:14.3％,30.5％;female:30.3％,40.2％) were significantly higher than those of the non-inflammatory group (P＜0.05);the positive rates of TRAb in male and female inflammatory groups (male:2.9 ％;woman:4.1％) were not significantly different from that of the non-inflammatory group.The prevalence of CLT in male and female inflammatory patients (male:16.2％;female,25.4％) was significantly higher than that in the corresponding non-inflammatory group (P＜0.01);the prevalence of GD in the male and female inflammatory patients (male:2.9 ％;female:4.1％) was not significantly different from that in the non-inflammatory group.The prevalence of subclinical hypothyroidism in the male and female inflammatory patients (male:21.9 ％;female:27.9 ％) was significantly higher than that in the non-inflammatory group (P＜0.01).The prevalence of hypothyroidism in the female inflammatory group (6.6％) was significantly higher than that in the female non-inflammatory group (P＜0.05).The prevalence of subclinical hyperthyroidism and clinical hyperthyroidism in male and female inflammatory patients and the prevalence of hypothyroidism in the male group were not significantly different from those in the non-inflammatory group.Conclusions:The positive rate of thyroid autoantibodies,the prevalence of CLT and the abnormal rate of thyroid function in patients with chronic tonsillitis are significantly higher.Chronic tonsillitis may be a risk factor for autoimmune thyroid damage.关键词
慢性扁桃体炎/自身免疫/慢性淋巴细胞性甲状腺炎/甲状腺自身抗体/患病率Key words
chronic tonsillitis/autoimmunity/chronic lymphocytic thyroiditis/thyroid autoantibodies/morbidity分类
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王永森,张朝赞,尹静,戴秀丽,周丽娜,顾世民..慢性扁桃体炎患者甲状腺自身免疫状态的临床分析[J].中国临床医学,2017,24(6):935-938,4.
