中国临床医学2017，Vol.24Issue(6)：943-945,3.DOI:10.12025/j.issn.1008-6358.2017.20160602
帕瑞昔布钠对气管插管全麻患者术后声音嘶哑与咽喉痛的影响
Effect of parecoxib sodium on incidence and severity of postoperative hoarseness and sore throat in general anesthesia patients
摘要
Abstract
Objective:To evaluate the effect of parecoxib sodium on the incidence and severity of postoperative hoarseness and sore throat in general anaesthesia patients.Methods:One hundred and twenty patients,with ASA physical status Ⅰ or Ⅱ,aged 20-60 yr,weighing 45-80 kg,undergoing general anesthesia were randomly allocated to parecoxib sodium group or normal saline group equally.In parecoxib sodium group,parecoxib sodium 40 mg was infused during induction of anesthesia,while the equal volume of 0.9％ normal saline was given instead in normal saline group.Anesthesia was intravenously induced with midazolam (0.05 mg/kg),sufentanyl (0.2-0.3 μg/kg),rocuronium (0.7 mg/kg) and propofol (2.0 mg/kg) and mechanical ventilation was applied after tracheal intubation in both groups.The incidence and severity of postoperative hoarseness and sore throat were evaluated 1,2,6,and 8 h after surgery.Results:Compared with normal saline group,the incidence and severity of postoperative hoarseness were significantly reduced by parecoxib sodium at 1,2,and 6 h time points in parecoxib sodium group (P＜0.05),except for time point of 8 h.The incidence and severity of postoperative sore throat was significantly reduced at 1,2,6,and 8 h time points in parecoxib sodium group,compared with normal saline group (P＜0.05).Conclusions:Parecoxib sodium provides efficacy in reducing the incidence and severity of postoperative hoarseness and sore throat in short term after surgery.关键词
帕瑞昔布钠/声音嘶哑/咽喉痛/全麻术后Key words
parecoxib sodium/hoarseness/sore throat/general anesthesia, postoperation分类
医药卫生引用本文复制引用
胡宝吉,敖翔,唐卫青,陆晓英,宋颖,谢鹏程,段宏伟..帕瑞昔布钠对气管插管全麻患者术后声音嘶哑与咽喉痛的影响[J].中国临床医学,2017,24(6):943-945,3.基金项目
上海市浦东新区优秀青年医学人才项目(PWRq2015-17).Supported by Young Medical Talents Training Program of Pudong Health Bureau of Shanghai(PWRq2015-17). （PWRq2015-17）
