中国比较医学杂志2018，Vol.28Issue(2)：1-6,6.DOI:10.3969.j.issn.1671-7856.2018.02.001
TRPV4受体对血管紧张素II诱导的小鼠肾损害的影响
Effect of TRPV4 on angiotensin II-induced renal injury in mice
摘要
Abstract
Objective This study was designed to determine the effect of transient receptor potential vanilloid type 4(TRPV4)on angiotensin Ⅱ(Ang Ⅱ)-induced renal injury in TRPV4-null mutant(TRPV4 -/-)mice. Methods The mice were divided into sham group and Ang Ⅱ-treated group. Ang Ⅱ was infused systemically into wild type(WT)and TRPV4 -/- mice via a miniosmotic pump for 4 weeks, and the sham mice were given with normal saline. Systolic blood pressure,urinary excretion of albumin and 8-isoprostane, serum creatinine, and the pathological changes in the kidney tissues were assayed after the 4-week treatment. Results Compared with corresponding sham mice,Ang Ⅱ infusion led to enhanced systolic blood pressure,increased urinary excretion of albumin and 8-isoprostane,increased serum creatinine(P< 0.05),and enhanced glomerulosclerosis degree and renal tubulointerstitial injury index(P< 0.05)in the WT and TRPV4 -/- mice. The result were associated with enhanced collagen levels in the kidney(P< 0.05). All of them were attenuated by the deletion of TRPV4 in the absence of alteration in blood pressure(P< 0.05). Conclusions Deletion of TRPV4 could alleviate renal injury during Ang Ⅱ-induced hypertension, suggesting that TRPV4 may contribute to the pathophysiology of angiotensin Ⅱ-induced renal injury.关键词
瞬时受体电位香草酸亚型4/血管紧张素II/高血压/肾脏损害Key words
TRPV4/angiotensin Ⅱ/hypertension/renal injury分类
医药卫生引用本文复制引用
闫凤娜,刘素晓,崔琳,谢世阳,沈思,朱明军,王幼平..TRPV4受体对血管紧张素II诱导的小鼠肾损害的影响[J].中国比较医学杂志,2018,28(2):1-6,6.基金项目
河南省科技攻关计划项目(162102410048) （162102410048）
国家自然科学基金面上项目(81170243). （81170243）
