中国比较医学杂志2018，Vol.28Issue(2)：20-25,6.DOI:10.3969.j.issn.1671-7856.2018.02.004
维生素D缺乏对自发性糖尿病大鼠发病的影响
Effect of vitamin D deficiency on pathogenesis of Zucker diabetic fatty rat
摘要
Abstract
Objective To investigate the effect of vitamin D(VD)deficiency on the pathogenesis of Zucker diabetic fatty(ZDF)rats. Methods Male 5-6 weeks old Zucker rats were randomly divided into 4 groups according to their body weight:normal control group(ZL),VD deficient control group(ZL+VD.Def),model group(ZDF)and VD deficient model group(ZDF+VD.Def). All the rats were fed to 12 weeks of age, and body weight, food intake, water intake,urine volume,urine glucose,fasting blood glucose were measured. The glucose tolerance was tested at 11 weeks. Pancreatic samples were taken and tissue sections were examined by pathology using HE staining. Results The body weight of ZDF+VD.Def group was higher than that of the ZDF group. Drinking water and urine volume were increased earlier than the ZDF rats. The blood glucose in the ZDF +VD. Def group was increased significantly earlier than ZDF group,it is about 2 times of the ZDF group at 12 weeks. Compared with the ZDF group,the impaired glucose tolerance and islet damage were more serious than the ZDF + VD. Def group. Conclusions Vitamin D deficiency accelerates and aggravates the pathogenesis of ZDF rats,and VD deficiency may be a key factor in the pathogenesis of obese DM Type 2.关键词
维生素D缺乏/自发性糖尿病大鼠(ZDF)/2型糖尿病Key words
vitamin D deficiency/Zucker diabetic fatty rat/ZDF rat/type 2 diabetes mellitus分类
医药卫生引用本文复制引用
李艳艳,王宁,刘妍妍,于微,刘涛,郝丽萍,王俊..维生素D缺乏对自发性糖尿病大鼠发病的影响[J].中国比较医学杂志,2018,28(2):20-25,6.基金项目
国家自然科学基金(81673168, 81703226) （81673168, 81703226）
广东省医学基金(20161159108949) （20161159108949）
深圳市科技计划项目(JCYJ20160428145633098,JCYJ20150402151501945) （JCYJ20160428145633098,JCYJ20150402151501945）
深圳市卫生计生系统科研项目(201605016). （201605016）
