中国肿瘤生物治疗杂志2018，Vol.25Issue(1)：9-16,8.DOI:10.3872/j.issn.1007-385x.2018.01.002
CRISPR-Cas基因编辑技术在泌尿系统肿瘤研究中的应用
The application of CRISPR-Cas gene editing technique in urinary system tumors
摘要
Abstract
The recent development of CRISPR-Cas systems (clustered regularly interspaced short palindromic repeat-clustered regularly interspaced short palindromic repeats associated system) as easily accessible and programmable tools for genome editing and regulation is spurring a revolution in biology.Experimental approaches based on this versatile technology have the potential to transform the field of cancer genetics.Here,we review current approaches for functional studies of urological cancer genes that are based on CRISPRCas systems,with emphasis on both advanced basic and translational urological research.关键词
成簇规律间隔短回文重复序列系统/泌尿系统肿瘤/基因编辑Key words
clustered regularly interspaced short palindromic repeat-clustered regularly interspaced short palindromic repeatsas sociated system(CRISPR-Cas)/urological cancer/gene editing分类
医药卫生引用本文复制引用
杨悦,訾晓渊,孙颖浩..CRISPR-Cas基因编辑技术在泌尿系统肿瘤研究中的应用[J].中国肿瘤生物治疗杂志,2018,25(1):9-16,8.基金项目
国家重大研发计划精准医疗专项基金项目(No.2016YFC0902200). Project supported by the National Special Fund for Precision Medical Research and Development (No.2016YFC0902200) （No.2016YFC0902200）
