北京中医药大学学报2018，Vol.41Issue(2)：165-170,6.DOI:10.3969/j.issn.1006-2157.2018.02.012
基于因子分析探讨1019例血脂异常患者的证候要素与靶标特点
Distribution of pattern elements and target organs in dyslipidemia:factor analysis of 1019 cases
摘要
Abstract
Objective To explore the distribution of pattern elements and target organs in dyslipidemia ai-ming at providing theoretical basis for dyslipidemia diagnosis and treatment in clinical practice.Methods A database matrix including clinical manifestations(containing 89 symptoms,physical signs,tongue and pulse)of 1019 patients with dyslipidemia.Factors were extracted according to initial models and rotated with Varimax,then the factor loading and the score of common factors was calculated.Pattern elements were concluded by the common factors,and the patients were grouped by the score of each pattern ele-ment.Thus the distribution of pattern elements and target organs were assigned according to its score of each group.Results 38 common factors and 14 pattern elements were extracted,from which 6 primary pattern elements were selected, including 3 excessive elements, phlegm(284 cases,25.08%), blood stasis(130 cases,11.48%), and heat(109 cases,9.62%)and 3 deficient elements, qi deficiency (170 cases,15.00%), yang deficiency(164 cases, 14.47%), and yin deficiency(108 cases, 9. 53%).8 target organs were extracted in which the main target included the spleen(508 cases, 40. 38%),lung(269 cases 21.38%), heart(218 cases,17.33%)and liver(190 cases, 5.25%). Conclusions Dyslipidemia in traditional Chinese medicine belongs to deficiency in its root(nature)and excess in branch(manifestation).Excessive manifestations include phlegm, blood stasis and heat, and deficient nature includes qi deficiency,yang deficiency and yin deficiency.The main symptom target(lo-cation)was the spleen,the lung,the heart and the liver.Therefore,the findings suggest that treatment of dyslipidemia in traditional Chinese medicine could rely on resolving phlegm, activating blood, remo-ving heat,tonifying qi,warming yang,and reinforcing yin.Spleen should be considered as the first and foremost organ in the treatment,while the lung,heart,and liver should also be taken into consideration.关键词
血脂异常/因子分析/证候要素/临床调查Key words
dyslipidemia/factor analysis/syndrome elements/clinical investigation分类
医药卫生引用本文复制引用
杨韬,何庆勇,钟小雪,刘旭东,王辉,郭建波,丁宇坤..基于因子分析探讨1019例血脂异常患者的证候要素与靶标特点[J].北京中医药大学学报,2018,41(2):165-170,6.基金项目
国家自然科学基金青年科学基金资助项目(No.81202803),中央公益性科研院所基本科研业务费专项资金资助项目(No.ZZ0908023)Young Scientists Fund of National Natural Science Foundation of China(No.81202803),Basic Scientific Research Special Project for Central Public Welfare Research Institutes(No.ZZ0908023) （No.81202803）
