北京中医药大学学报2018，Vol.41Issue(2)：171-176,6.DOI:10.3969/j.issn.1006-2157.2018.02.013
热敏灸配合常规药物治疗膝骨性关节炎阳虚寒凝证的临床疗效观察
Effects of heat-sensitized moxibustion combined with conventional medi-cine on knee osteoarthritis of yang-deficiency cold-congealing pattern: a clinical trial
摘要
Abstract
Objective To explore the effects of heat-sensitized moxibustion combined with conventional medicine on knee osteoarthritis(KOA)including clinical efficacy and cytokine levels.Methods 60 pa-tients with bilateral knee osteoarthritis was divided into two groups(n=30).The treatment group was given heat-sensitized moxibustion combined with conventional drugs,while the control group was adminis-tered with routine acupuncture treatment besides conventional drugs.Bilateral ST35,GB34,and EX-LE2 were selected as treating acupoints for 15 minutes once a day for 6 days as one treatment session.Four treatment sessions were one total treatment course, with 1-day interval between two sessions.The Ly-sholm knee function score was applied to evaluate clinical efficacy before and after treatment.The scores of joint pain,joint swelling,and walking ability and cytokine TNF-α/IL-1 were also compared before and after treatment.Criteria of adverse effect factors was adopted to evaluate the safety.Results The scores of joint pain,joint swelling, walking ability and serum cytokines TNF-α/IL-1of patients in both groups were improved after treatment(P<0.05).Compared with the control group, those above index in the treatment group were improved more markedly(P<0.01).The effective rate of the treatment group and control group was 86.7%,and 66.7%respectively,thus the efficacy of treatment group was significantly superior to that of the control group(P<0.01).Moreover,compared with control group,there were less adverse effects in treatment group(P<0.05).Conclusion To treat knee osteoarthritis,heat-sensitized moxibustion appears to be superior to routine moxibustion therapy in terms of efficacy and safety.The non-invasive heat-sensitized moxibustion may alleviate symptoms,and improve physical signs effectively, which warrants further exploration and development.关键词
热敏灸/膝骨性关节炎/细胞因子/疗效/不良反应Key words
heat-sensitized moxibustion/knee osteoarthritis/cytokine/efficacy/adverse effect分类
医药卫生引用本文复制引用
王智琴,谢洪武,刘福水,焦琳,陈日新..热敏灸配合常规药物治疗膝骨性关节炎阳虚寒凝证的临床疗效观察[J].北京中医药大学学报,2018,41(2):171-176,6.基金项目
国家重点基础研究发展计划(973计划)资助项目(No.2015CB554503),江西省卫生计生委项目(No.2014B034)National Basic Research Program of China(No.2015CB554503),Jiangxi Provincial Health and Family Planning Commission Project(No.2014B034) （973计划）
