大学化学2018，Vol.33Issue(1)：1-6,6.DOI:10.3866/PKU.DXHX201711035
冷冻电镜技术应用于生物分子高分辨结构解析——2017年诺贝尔化学奖浅谈
Cryo-EM Method for High-Resolution Structure Determination: A Brief Introduction to 2017 Nobel Prize in Chemistry
李治非 1高宁1
作者信息
- 1. 北京大学生命科学学院,北京大学-清华大学生命联合中心,膜生物学国家重点实验室,北京 100871
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摘要
Abstract
The 2017 Nobel Prize in chemistry was awarded to Jacques Dubochet, Joachim Frank and Richard Henderson for their contribution to developing the cryo-electron microscopy (cryo-EM) method for high-resolution structure determination of biomolecules in solution. In recent years, cryo-EM is leading a revolution in structural biology, and becoming a major tool in studying the structure and function of biomolecular machines. Here, we briefly describe the method development of cryo-EM and the personal contributions of the three Nobel Laureates.关键词
冷冻电镜/生物大分子/结构生物学/诺贝尔化学奖Key words
Cryo-electron microscopy/Biomolecules/Structural biology/Nobel Prize in chemistry分类
社会科学引用本文复制引用
李治非,高宁..冷冻电镜技术应用于生物分子高分辨结构解析——2017年诺贝尔化学奖浅谈[J].大学化学,2018,33(1):1-6,6.
