分析化学2018，Vol.46Issue(3)：301-310,10.DOI:10.11895/j.issn.0253-3820.171024
热休克蛋白90的分子伴侣调控与癌症研究进展
Progress in Molecular Chaperone Regulation of Heat Shock Protein 90 and Cancer
摘要
Abstract
Heat shock protein 90 (HSP90) is a member of genetically conserved heat shock protein family. As an important molecular chaperone in eukaryotic cells, HSP90 plays a key regulatory role in maintaining cellular protein homeostasis. HSP90 clients encompass a wide range of proteins, thus HSP90 is involved in diverse biological process. With the deeper study, it is found that HSP90 takes an important part in the development and metastasis of cancer,and has become a promising target for the study of anticancer biology. We review the progress of HSP90 as molecular chaperone and its relationship with cancer.关键词
热休克蛋白90/分子伴侣/癌症/评述Key words
Heat shock protein 90/Molecular chaperone/Cancer/Review引用本文复制引用
翟睿,龚晓云,熊行创,江游,黄泽建,方向..热休克蛋白90的分子伴侣调控与癌症研究进展[J].分析化学,2018,46(3):301-310,10.基金项目
本文系国家重点研发计划项目(Nos.2016YFF0200502,2016YFF0200504,2016YFF0102603)资助 This work was supported by the National Key Research and Development Program of China(Nos.2016YFF0200502,016YFF0200504,2016YFF0102603). （Nos.2016YFF0200502,2016YFF0200504,2016YFF0102603）
