摘要
Abstract
Objective To evaluate the curative effect and safety of Peramivir in treatment of children suspected with influenza(flu). Methods The children suspected with influenza in Beijing Children's Hospital during June 2016 to January 2017 were selected. Prospective study method was adopted in this study.And the children and their guardians who agreed to accept the intravenous injection of Peramivir,a new medicine for treatment,were divided into treatment group(n=180),while the children and their guardian who refused intravenous injection of Peramivir were treated with conventional therapy by oral administration of Ibuprofen suspensions and other symptomatic drugs and were divided into control group(n=180).The average fever relief time,average symptom relief time and adverse reactions of children in two groups were evaluated.Results There was no significant difference in gender and age of children between two groups(both P>0.05).And the differences in the average time during symptom appearing to drug administration before treatment and mean body temperature between two groups were not statistically significant(both P>0.05).After treatment,the average fever relief time of the treatment group and the control group were 16.38 ± 7.34 hours and 60.20 ± 32.52 hours,respectively,and the average symptom relief time of the treatment group and the control group were 45.77 ± 27.58 hours and 65.43 ± 33.44 hours,respectively.The average fever relief time,average symptom relief time,the relief time of main symptoms such as cough,sore throat,nasal catarrh/rhinobyon of children in the treatment group were significantly less than those of children in the control group(t value was -17.988,-7.301, -8.488,-11.080 and -10.641,respectively,all P<0.05).In the treatment group,there were 6 children presenting nausea,diarrhea and other gastrointestinal reactions,while in the control group,there were 5 children presenting nausea,vomiting and other gastrointestinal reactions.The difference between two groups was not statistically significant(P>0.05).All the adverse reactions were not treated with special treatment and gradually relieved and disappeared with the improvement of disease.The usage rate of antibiotics in the treatment group and the control group were 12.78% and 41.11%,respectively.The difference between two groups was statistically significant(χ2=36.704,P<0.05).Conclusion In treatment of children suspected with influenza,Peramivir can significantly and rapidly relieve the symptoms and reduce the usage of antimicrobials with good safety and tolerability.关键词
流行性感冒/帕拉米韦/儿童/疑似Key words
influenza/Peramivir/children/suspected分类
医药卫生
