国际口腔医学杂志2018，Vol.45Issue(2)：135-139,5.DOI:10.7518/gjkq.2018.02.003
CD20在口腔潜在恶性病变中的表达及其临床意义
Clinical significance of CD20 expression in oral potentially malignant disorders
摘要
Abstract
Objective This study aims to investigate the expression of C20 in oral potentially malignant disorders (OPMDs) by using the histological analysis and evaluates the clinical value of using CD20 as indices to assess the carcinogenic potential of OPMDs. Methods Clinical data from 17 cases with oral hyperplasia mucosa, 21 cases with oral lichen planus (OLP), 15 cases with mild oral dysplasia mucosa (D1), and 9 cases with mild moderate dysplasia mucosa (D2) were analyzed by using retrospective analysis. Immunohistochemical analysis was applied to investigate the expression of CD20 in paraffin sections of oral hyperplasia mucosa, OLP, D1, and D2 tissues. Subsequently, the relationships between such expression and clinical factors were investigated. Results The positive rates of CD20 expression in the oral hyperplasia mucosa, OLP, D1, and D2 mucosa were 11.76%, 61.90%, 20.00%, and 66.67% (P<0.05), respectively. CD20 expression was found uncorrelated with age, gender, region, alcohol use, and smoking status (P>0.05). The multiple-factor analysis showed that the odds ratios of OLP and D2 significantly increased (P<0.05) when oral hyperplasia mucosa was used as the reference group. Conclusion CD20 may be used individually as clinical index to evaluate the carcinogenic potential of OPMDs.关键词
CD20/B细胞/口腔潜在恶性病变Key words
CD20/B cell/oral potentially malignant disorders分类
医药卫生引用本文复制引用
刘奕,周昊,费伟..CD20在口腔潜在恶性病变中的表达及其临床意义[J].国际口腔医学杂志,2018,45(2):135-139,5.基金项目
国家自然科学基金(81502362)This study was supported by National Natural Science Foundations of China(81502362). （81502362）
