国际口腔医学杂志2018，Vol.45Issue(2)：209-213,5.DOI:10.7518/gjkq.2018.02.015
双甲基丙烯酸二缩三乙二醇酯细胞毒性的研究进展
Cytotoxic mechanism of triethylene glycol dimethacrylate
摘要
Abstract
Cell toxicity is a pure cell killing event caused by a cell or chemical substances. The chemical substances act on the basic structure of the cell and/or physiological processes, such as cell membrane and cytoskeleton structure, cell metabolism, synthesis of cellular components or products, degradation or release, ion regulation and cell division. Which leads to adverse reactions such as cell survival, proliferation and/or functional disorder. Triethylene glycol dimethacrylate (TEGDMA) is a commonly used diluent of many resin-based dental composites. It is an important relevant monomer responsible for the cytotoxicity of the resin matrix. The monomer can lead to a series of toxic reactions, such as oxidative imbalance, apoptosis, DNA damage and so on. In this paper, the research advances in mechanism of cytotoxicity induced by TEGDMA monomer is reviewed, the aim is to lay the foundation for further clarifying the mechanism of toxicity and to reduce or eliminate the toxic effect.关键词
双甲基丙烯酸二缩三乙二醇酯/氧化应激/细胞毒性/基因毒性/细胞凋亡Key words
triethylene glycol dimethacrylate/oxidative stress/cytotoxicity/gene toxicity/apoptosis分类
生物科学引用本文复制引用
陈秀春,张志民,洪丽华,张雅琪,郑鹏,李文月..双甲基丙烯酸二缩三乙二醇酯细胞毒性的研究进展[J].国际口腔医学杂志,2018,45(2):209-213,5.基金项目
吉林省产业创新专项资金(2016c045-3)This study was supported by the Special Funds for Provincial Industrial Innovation in Jilin Province(2016c045-3). （2016c045-3）
