海南医学院学报2018，Vol.24Issue(2)：165-168,4.DOI:10.13210/j.cnki.jhmu.20180105.027
α-硫辛酸对糖尿病肾病患者氧化应激、血管内皮及肾功能的影响
Effects of α-lipoic acid on oxidative stress, vascular endothelium function and renal function in patients with diabetic nephropathy
摘要
Abstract
Objective:To investigate the effects of α-lipoic acid on oxidative stress,vascular endothelium function and renal function in diabetic nephropathy patients.Methods:According to random data table method,a total of 80 patients with diabetic nephropathy from September 2016 to August 2017 were divided into observation group and control group (n =40).Patients in control group were treated with routine therapy,while those who were in observation group were given intravenous infusion of α-lipoic acid on the basis of conventional therapy.The levels of oxidative stress,vascular endothelium function and renal function changes were compared between the two groups before and after the treatment.The levels of SOD,MDA,NO,ET-1,RBP and CysC in the two groups before treatment were not statistically significant (P＞0.05).Compared with before treatment,the levels of SOD in the observation group were significantly increased and the levels of MDA were significantly decreased(P＜0.05);the level of SOD in the observation group was significantly higher than that in the control group(P＜0.05),and the level of MDA was significantly lower than that of the control group(P＜0.05);the above differences were statistically significant(P＜0.05).The levels of SOD and MDA were no significant changes in the control group before and after treatment.After treatment,the levels of ET-1,RBP and CysC in the two groups were significantly lower than those in the same group before treatment (P ＜ 0.05),and the observation group levels were significantly lower than those in the control group (P ＜ 0.05);the levels of NO in the two groups after treatment were significantly higher than those in the same group before treatment (P＜0.05),and the observation group was significantly higher than that of the control group (P ＜0.05);the above differences were statistically significant.Conclusions:α-lipoic acid on the basis of conventional treatment can better reduce the level of oxidative stress,improve vascular endothelial function,renal function in patients with diabetic nephropathy,which has important clinical value.关键词
α-硫辛酸/糖尿病肾病/氧化应激/血管内皮功能/肾功能Key words
α-lipoic acid/Diabetic nephropathy/Oxidative stress/Vascular endothelium function/Renal function分类
医药卫生引用本文复制引用
屈春梅,陈书梅,张又之,方超..α-硫辛酸对糖尿病肾病患者氧化应激、血管内皮及肾功能的影响[J].海南医学院学报,2018,24(2):165-168,4.基金项目
重庆市卫生科技计划项目(20151248)This study was supported by Chongqing Municipal Health Science and Technology Project (Grant No.20151248). （20151248）
