海南医学院学报2018，Vol.24Issue(2)：191-194,4.DOI:10.13210/j.cnki.jhmu.20171229.001
脑脊液和血浆生化指标比值对结核性及化脓性脑膜炎的鉴别意义
Significance of cerebrospinal fluid and plasma biochemical indicator ratio in identifying the tuberculous meningitis and purulent meningitis
摘要
Abstract
Objective:To explore the significance of cerebrospinal fluid (CSF) and plasma biochemical indicator ratio in identifying the tuberculous meningitis and purulent meningitis.Methods:A total of 43 patients with tuberculous meningitis who were admitted in our hospital from August,2015 to July,2017 were included in the study and served as the tuberculous meningitis group.Moreover,40 cases with purulent meningitis were served as the purulent meningitis group.The morning fasting peripheral venous blood was collected and centrifuged for the plasma.Lumbar puncture was used to collect CSF.The fully automatic biochemical analyzer was used to detect GSH,the plasma protein,chloride,glucose,lactic acid,and ADA.GSF/plasma ratio was calculated.The immunity transmission turbidity was used to detect GSH and Cys-C.FCM was used to detect CD64.ELISA was used to detect MMP-9.Results:GSF chloride and lactic acid in the tuberculous meningitis group were significantly lower than those in the purulent meningitis group,while ADA was significantly higher than that in the purulent meningitis group (-P＜0.01).The plasma protein,chloride,and lactic acid in the tuberculous meningitis group were significantly lower than those in the purulent meningitis group,while ADA was significantly higher than that in the purulent meningitis group (P ＜0.01).ADA ratio in GSF in the tuberculous meningitis group was significantly higher than that in the purulent meningitis group,while chloride and lactic acid ratio was significantly lower than that in the purulent meningitis group (P＜0.01).CD64 in GSF in the tuberculous meningitis group was significantly lower than that in the purulent meningitis group,and MMP-9 was significantly higher than that in the purulent meningitis group (P ＜0.01),while the comparison of Cys-C between the two groups was not statistically significant (P＞0.05).Conclusions:GSF,plasma protein,chloride,lactic acid,and ADA concentration ratio in the tuberculous meningitis group and purulent meningitis group have a certain difference.Combined detection of CD64 and MMP-9 contribute to identify the two meningitis.关键词
脑脊液/血浆/生化指标比值/化脓性脑膜炎/结核性脑膜炎Key words
CSF/Plasma/Biochemical indicator ratio/Purulent meningitis/Tuberculous meningitis分类
医药卫生引用本文复制引用
周国云..脑脊液和血浆生化指标比值对结核性及化脓性脑膜炎的鉴别意义[J].海南医学院学报,2018,24(2):191-194,4.基金项目
河北省科学技术支撑项目(20142053)The study was supported by the Scientific and Technological Support Project of Hebei Province (Grant No.20142053). （20142053）
