海南医学院学报2018，Vol.24Issue(2)：202-205,209,5.DOI:10.13210/j.cnki.jhmu.20180105.001
结肠癌组织中SphK1和FAK表达量与临床病理特征、上皮间质转化的相关性研究
The correlation of SphK1 and FAK expression in colon cancer tissue with clinical pathological features and epithelial-mesenchymal transition
摘要
Abstract
Objective:To investigate the correlation of SphK1 and FAK expression in colon cancer tissue with clinical pathological features and epithelial-mesenchymal transition (EMT).Methods:90 patients with colon cancer who received radical operation for colon cancer in our Hospital between January 2015 and May 2017 were selected as colon cancer group,and 48 patients with intestinal perforation who received emergency surgery in this hospital during the same period were selected as control group.The differences in the expression of SphK1,FAK as well as proliferation,invasion and EMT marker genes in lesion tissue were compared between the two groups.Pearson test was used to evaluate the correlation of SphK1 and FAK gene expression with the malignant biological characteristics of tumor and EMT in colon cancer tissues.Results:SphK1 and FAK mRNA expression in lesion tissue of colon cancer group were higher than those of control group;proliferation-related genes Mina53,GTPBP4,CXCR7 and EZH2 mRNA expression were higher than those of control group whereas MS4A12 mRNA expression was lower than that of control group;invasion-related genes Lin28A,PRDX1,PRM1 and SLP-2 mRNA expression were higher than those of control group whereas ZNRD1 mRNA expression was lower than that of control group;EMT marker gene E-cadherin mRNA expression was lower than that of control group whereas N-cadherin and vimentin mRNA expression were higher than those of control group.Pearson test showed that the SphK1 and FAK gene expression in colon cancer tissue were positively correlated with the tumor proliferation and invasion activity and the EMT process.Conclusion:SphK1 and FAK gene expression are abnormal in colon cancer tissue and can increase the proliferation and invasion activity of tumor cells and accelerate the EMT process.关键词
结肠癌/SphK1/FAK/增值/侵袭/上皮间质转化Key words
Colon cancer/SphK1/FAK/Proliferation/Invasion/Epithelial-mesenchymal transition分类
医药卫生引用本文复制引用
李博,邓睿,李栋,徐小东..结肠癌组织中SphK1和FAK表达量与临床病理特征、上皮间质转化的相关性研究[J].海南医学院学报,2018,24(2):202-205,209,5.基金项目
陕西省科学技术研究发展计划项目(2012K16-09-014)This study was supported by Shaanxi Science and Technology Research and Development Plan Project (grant No.2012K16-09-014). （2012K16-09-014）
