海南医学院学报2018，Vol.24Issue(2)：210-212,3.DOI:10.13210/j.cnki.jhmu.20180102.003
不同剂量右美托咪定复合丙泊酚在老年无痛肠镜检查中的应用
Application of dexmedetomidine in different doses in combined with propofol in the painless colonoscopy in the elder patients
摘要
Abstract
Objective:To explore the anesthetic effect of dexmedetomidine (Dex) in different doses in combined with propofol on the painless colonoscopy in the elder patients.Methods:A total of 60 elder patients who were admitted in our hospital from November,2016 to October,2017 for selective painless fiber colonoscopy were included in the study and divided into the low dose group and high dose group according to Dex dose.The micro-infusion pump was used to inject Dex 10 min before examination.The load capacity in the low dose group was 0.25 μg/kg,while in the high dose group was 0.75 μg/kg.The pump injection was completed within 10 min,then a continuous pump injection was performed in a speed of 0.5 μg/kg/h until the check off.After the completion of Dex pumping,propofol (1～1.5 mg/kg) was slowly injected.MAP,HR,and SpO2 before medication (T0),5 min after inserting the endoscope (T1),and the time after the examination being finished (T2) were recorded,respectively.The bioelectrical impedance technic was used to continuously monitor SV,CO,and SVR.The awakening time,propofol dose,and discharge time were recorded.Results:The comparison of MAP,HR,and SpO2 at T0 between the two groups was not statistically significant (P＞0.05).MAP,HR,SV,CO,and SVR at T1 and T2 were significantly lower than those at T0(P＜0.05),while the comparison of SpO2 was not significantly changed (P＞0.05).MAP at T1 in the high dose group was significantly higher than that in the low dose group,while HR at T1 and T2 was significantly lower than that in the low dose group (P＜0.05).SV,CO,and SVR at T1 and T2 in the high dose group was significantly higher than those in the low dose group (P＜0.05).The awakening time in the high dose group was significantly shorter than that in the low dose group,and the propofol dose was significantly less than that in the low dose group (P＜0.05),while the comparison of discharge time was not significantly different (P ＞0.05).Conclusions:Application of Dex in a high dose in the painless colonoscopy in the elder patients can reduce the propofol dose,and will not increase the inhibiting effect on respiration and circulation.关键词
右美托咪定/丙泊酚/老年/纤维结肠镜Key words
Dex/Propofol/Agedness/Fiber colonscope分类
医药卫生引用本文复制引用
李彦君,张建新..不同剂量右美托咪定复合丙泊酚在老年无痛肠镜检查中的应用[J].海南医学院学报,2018,24(2):210-212,3.基金项目
河北省卫生和计划生育委员会重点科技研究计划项目(20171429)This study was supported by Key Science and Technology Research Project of Hebei Provincial Health and Family Planning Commission (20171429). （20171429）
