海南医学院学报2018，Vol.24Issue(2)：213-215,219,4.DOI:10.13210/j.cnki.jhmu.20180105.009
老年卵巢癌患者血清CA125、HE4及ROMA指数变化的价值研究
Study on the value of serum CA125, HE4 and ROMA index in elderly patients with ovarian cancer
摘要
Abstract
Objective:To study the value of serum tumor markers,carbohydrate antigen 125 (CA125),human epididymis secretory protein 4 (HE4) and ovarian cancer risk factor (ROMA) index in elderly patients with ovarian cancer,so as to provide a choice for clinical diagnosis.Methods:A total of 110 cases of ovarian cancer treated in our hospital in December-2017 December 2015 were selected as malignant group.In addition,120 cases of benign ovarian tumors in the same period were selected as the benign group,and 92 healthy women who came to the hospital for health examination were selected as the control group.The three groups were detected by microparticle enzyme immunochemiluminescence assay in serum HE4,CA125 levels and positive rates,and ROMA index values were combined to assess the risk of ovarian cancer.Results:Three groups of patients in malignant group serum CA125,HE4 level and ROMA index were significantly higher than those in the benign group and the control group (P＜0.05),the level of CA125 positive group was higher than control group (P＜0.05),but the level of HE4 and ROMA index in benign group compared with the control group,the difference was not statistically significant (P＞ 0.05).Compared with the positive rate,the positive rates of serum CA125,HE4 and ROMA index in malignant group were 76.4％,92.7％,96.4％,which were higher than those in benign group (28.3％,18.3％,15％),and the difference was statistically significant (P＜0.05).Compared with the diagnostic efficiency,the negative predictive value,positive predictive value,specificity and sensitivity of CA125 were all lower than those of HE4.The negative predictive value,positive predictive value,specificity and sensitivity of the combined ROMA index were higher than those of single diagnosis.Conclusion:serum CA125,HE4 and ROMA index in elderly patients with ovarian cancer are significantly higher than those in elderly patients with benign ovarian tumors and healthy women.The combined diagnosis is the highest,with Gao Min's high sensitivity and specificity,which can be popularized in clinical practice.关键词
老年卵巢癌/糖类抗原125/人附睾分泌蛋白4/卵巢癌恶性风险模型Key words
Elderly ovarian cancer/Carbohydrate antigen 125/Epididymal secretory protein 4/Malignant risk model of ovarian cancer分类
医药卫生引用本文复制引用
王艳君,杜秀娟..老年卵巢癌患者血清CA125、HE4及ROMA指数变化的价值研究[J].海南医学院学报,2018,24(2):213-215,219,4.基金项目
陕西省自然基金研究计划(2016JM8110)This study was supported by Natural Foundation Research Project of Shaanxi Province (2016JM8110). （2016JM8110）
