海南医学院学报2018，Vol.24Issue(2)：216-219,4.DOI:10.13210/j.cnki.jhmu.20180105.023
新辅助化疗不同给药途径对宫颈癌组织中癌细胞生长信号通路功能的影响
Effects of different administration routes of neoadjuvant chemotherapy on cancer cell growth signal pathway function in cervical cancer
摘要
Abstract
Objective:To study the effects of different administration routes of neoadjuvant chemotherapy on cancer cell growth signal pathway function in cervical cancer.Methods:Patients with cervical cancer who received neoadjuvant chemotherapy in Fufeng People's Hospital between July 2008 and July 2016 were selected as the research subjects and randomly divided into intervention group and intravenous group who accepted the neoadjuvant interventional arterial chemotherapy and neoadjuvant intravenous chemotherapy respectively.After surgical resection,the contents of PI3K/AKT/mTOR,Wnt/β-catenin and MEK/ERK signaling pathway in cervical cancer lesions were determined.Results:p-PI3K,p-AKT,mTOR,MMP2,VEGF,β-catenin,CyclinD1,Twist,Slug,Snail,MEK1,MEK2,ERK1/2 and Bcl-2 protein levels in cervical cancer lesion of intervention group were significantly lower than those of intravenous group whereas E-cadherin and Bax protein levels were significantly higher than those of intravenous group.Conclusion:Neoadjuvant interventional arterial chemotherapy can be more effective than neoadjuvant intravenous chemotherapy to inhibit the cancer cell growth mediated by PI3K/AKT/mTOR,Wnt/β-catenin and MEK/ERK signaling pathway in cervical cancer.关键词
宫颈癌/新辅助化疗/介入动脉化疗/信号通路Key words
Cervical cancer/Neoadjuvant chemotherapy/Interventional arterial chemotherapy/Signaling pathway分类
医药卫生引用本文复制引用
白煜..新辅助化疗不同给药途径对宫颈癌组织中癌细胞生长信号通路功能的影响[J].海南医学院学报,2018,24(2):216-219,4.基金项目
陕西省科学技术研究发展计划项目(2009k12-01)This study was supported by Science and Technology Research Development Project of Shaanxi Province (2009k12-01). （2009k12-01）
