海南医学院学报2018，Vol.24Issue(2)：224-227,4.DOI:10.13210/j.cnki.jhmu.20171226.003
百令胶囊联合炔雌醇环丙孕酮、二甲双胍对多囊卵巢综合征患者脂代谢、胰岛素抵抗的影响
Effect of Bailing capsule combined with ethinylestradiol and cyproterone acetate and metformin on lipid metabolism and insulin resistance in patients with polycystic ovary syndrome
摘要
Abstract
Objective:To investigate the effect of Bailing capsule combined with ethinylestradiol and cyproterone acetate and metformin on lipid metabolism and insulin resistance in patients with polycystic ovary syndrome (PCOS).Methods:A total of 108 patients with PCOS who were treated in our hospital between November 2014 and April 2017 were reviewed and divided into routine group (n =67) who received routine therapy and Bailing capsule group (n =41) who received Bailing capsule combined with routine therapy.Routine group received ethinylestradiol and cyproterone acetate and metformin therapy,and Bailing capsule group were treated with Bailing capsule combined with ethinylestradiol and cyproterone acetate and metformin therapy.The differences in the levels of lipid metabolism,insulin resistance indexes as well as inflammatory factors were compared between the two groups before and after treatment.Results:There was no statistically significant difference in serum levels of lipid metabolism,insulin resistance-related indexes and inflammatory factors between the two groups before treatment.After treatment,serum HDL-C content of Bailing capsule group was higher than that of routine group whereas LDL-C and TC contents were lower than those of routine group;serum insulin resistance-related indexes FINS and HOMA-IR levels were lower than those of routine group;serum inflammatory cytokines IL-6,TNF-α,APN and LEP contents were lower than those of routine group.Conclusion:Bailing capsule combined with ethinylestradiol and cyproterone acetate and metformin therapy can effectively improve the lipid metabolism level and inhibit the insulin resistance in patients with PCOS.关键词
多囊卵巢综合征/百令胶囊/脂代谢/胰岛素抵抗Key words
Polycystic ovary syndrome/Bailing capsule/Lipid metabolism/Insulin resistance分类
医药卫生引用本文复制引用
刘妮,皮丹,刘春梅..百令胶囊联合炔雌醇环丙孕酮、二甲双胍对多囊卵巢综合征患者脂代谢、胰岛素抵抗的影响[J].海南医学院学报,2018,24(2):224-227,4.基金项目
黔科计(2016056)This study was supported by the Science and Technology Project of the People's Government of Qianjiang District,Chongqing (2016056). （2016056）
