海南医学院学报2018，Vol.24Issue(2)：228-230,234,4.DOI:10.13210/j.cnki.jhmu.20180105.012
子痫前期胎盘中MiR-26b表达的变化趋势及其下游靶基因的研究
The changes of miR-26b expression in the preeclampsia placenta and its downstream target genes
摘要
Abstract
Objective:To study the changes of miR-26b expression in the preeclampsia placenta and its downstream target genes.Methods:Preeclampsia placenta tissue and healthy placenta tissue from puerperae who gave birth in Songzi People's Hospital between August 2014 and February 2017 were collected,miRNA was extracted to determine miR-26b expression,and protein was extracted to detect he expression of cell invasion molecules MEST,LAMA4,uPA,HtrA4 and CTSB as well as angiogenesis molecules VEGF,ANG1,ANG2 and PLGF.Results:miR-26b expression in preeclampsia placenta tissue was significantly higher than that in healthy placenta tissue whereas MEST,LAMA4,uPA,HtrA4,CTSB,VEGF,ANG1,ANG2 and PLGF protein expression were significantly lower than those in healthy placenta tissue;MEST,LAMA4,uPA,HtrA4,CTSB,VEGF,ANG1,ANG2 and PLGF protein expression in preeclampsia placenta tissue with high miR-26b expression were significantly lower than those in preeclampsia placenta tissues with low miR-26 expression.Conclusion:miR-26b is highly expressed in the preeclampsia placenta tissue and the target genes are cell invasion molecules and angiogenesis molecules.关键词
子痫前期/miR-26b/细胞侵袭/血管新生Key words
Preeclampsia/miR-26b/Cell invasion/Angiogenesis分类
医药卫生引用本文复制引用
王义蓉,孟运莲..子痫前期胎盘中MiR-26b表达的变化趋势及其下游靶基因的研究[J].海南医学院学报,2018,24(2):228-230,234,4.基金项目
荆州市科技一般项目(15XB3208)This study was supported by Jingzhou Science and Technology General Project (15XB3208). （15XB3208）
