海南医学院学报2018，Vol.24Issue(2)：246-249,4.DOI:10.13210/j.cnki.jhmu.20180105.010
利卡汀联合吡柔比星TACE对不可切除肝癌组织中细胞凋亡及上皮间质转化的影响
Effect of licartin combined with pirarubicin TACE on apoptosis and epithelial-mesenchymal transition in unresectable liver cancer tissue
摘要
Abstract
Objective:To study the effect of licartin combined with pirarubicin transcatheter arterial chemoembolization (TACE) on apoptosis and epithelial-mesenchymal transition in unresectable liver cancer tissue.Methods:Patients with unresectable liver cancer who were treated in Navy General Hospital between May 2014 and October 2016 were selected and randomly divided into two groups,the licartin group received licartin combined with TACE therapy,and control group received TACE therapy alone.The expression of tumor suppressor genes,autophagy marker genes and epithelial-mesenchymal transition marker genes in liver cancer lesions were determined before and after treatment.Results:After operation,RNF180,EBLN2,ALKBH5,Merlin,Beclin-1,LC3-Ⅱ,TRAF-6 and E-cadherin protein expression in liver cancer lesions of both groups of patients were significantly higher than those before operation while Shh,Gli1,Snail,Twist,N-cadherin and Vimentin protein expression were significantly lower than those before operation,and RNF180,EBLN2,ALKBH5,Merlin,Beclin-1,LC3-Ⅱ,TRAF-6 and E-cadherin protein expression in liver cancer lesions of licartin group were significantly higher than those of control group while Shh,Gli1,Snail,Twist,N-cadherin and Vimentin protein expression were significantly lower than those of control group.Conclusion:Licartin combined with pirarubicin TACE for unresectable liver cancer can more effectively induce apoptosis and autophagy,and inhibit epithelial-mesenchymal transition.关键词
肝癌/利卡汀/肝动脉化疗栓塞术/凋亡/上皮间质转化Key words
Liver cancer/Licartin/Transcatheter arterial chemoembolization/Apoptosis/Epithelial-mesenchymal transition分类
医药卫生引用本文复制引用
张嘉诚,田艳云,杨超,马军朋,蒋富强,杨剑,卢伟..利卡汀联合吡柔比星TACE对不可切除肝癌组织中细胞凋亡及上皮间质转化的影响[J].海南医学院学报,2018,24(2):246-249,4.基金项目
国家自然科学基金(30670612) （30670612）
中华国际医学交流基金会(Z-2014-06-15322) （Z-2014-06-15322）
海军后勤部(HJHQ-20130987)This study was supported by National Natural Science Foundation of China (30670612),China International Medical Foundation (Z-2014-06-15322) and Logistics Department of People's Liberation Army Navy (HJHQ-20130987). （HJHQ-20130987）
